Anaphylaxis with<i>Anisakis simplex</i>in the Gastric Mucosa

Alonso, A.; Daschner, Álvaro; Moreno-Ancillo, A

doi:10.1056/nejm199707313370518

Cited by 73 publications

(61 citation statements)

References 3 publications

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“…Sensitisation may occur to both live parasites, or to parasitised food in which worms have been killed by cooking or pasteurisation. Sensitisation may result in urticaria, angioedema or anaphylaxis after eating infected seafood [19]. Indeed, this syndrome may be responsible for a signi®cant proportion of cases of so-called idiopathic eosinophilic gastroenteritis [20].…”

Section: Anisakidosismentioning

confidence: 99%

Emerging helminth zoonoses

McCarthy

Moore

2000

International Journal for Parasitology

208

133

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Section: Anisakidosismentioning

confidence: 99%

Emerging helminth zoonoses

McCarthy

Moore

2000

International Journal for Parasitology

208

133

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“…Several species of larval nematodes including Anisakis larvae undergo extensive migration within their intermediate hosts, and the migrated visceral larvae cause a severe inflammatory disease characterized by hepatomegaly, eosinophilia, and hypergammaglobulinemia (22)(23)(24). Encapsulation of the larvae by the host certainly prevents their migration and growth, and may function as a major defense system against larval infection.…”

Section: Aip Predominantly Localizes In the Inner Cavity Of Capsule Smentioning

confidence: 99%

Purification and Cloning of an Apoptosis-Inducing Protein Derived from Fish Infected with Anisakis simplex, a Causative Nematode of Human Anisakiasis

Jung

Mai

Iwamoto³

et al. 2000

The Journal of Immunology

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While investigating the effect of marine products on cell growth, we found that visceral extracts of Chub mackerel, an ocean fish, had a powerful and dose-dependent apoptosis-inducing effect on a variety of mammalian tumor cells. This activity was strikingly dependent on infection of the C. mackerel with the larval nematode, Anisakis simplex. After purification of the protein responsible for the apoptosis-inducing activity, we cloned the corresponding gene and found it to be a flavoprotein. This protein, termed apoptosis-inducing protein (AIP), was also found to possess an endoplasmic reticulum retention signal (C-terminal KDEL sequence) and H2O2-producing activity, indicating that we had isolated a novel reticuloplasimin with potent apoptosis-inducing activity. AIP was induced in fish only after infection with larval nematode and was localized to capsules that formed around larvae to prevent their migration to host tissues. Our results suggest that AIP may function to impede nematode infection.

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“…With regard to the harmful effects of these parasites on human health, various authors have produced contradictory results/conclusions about the efficacy of salting to inactivate helminth larvae (RAMOS, 2011). Some authors claim that only live parasites can affect human health (ALONSO et al, 1997;RODRÍGUEZ et al, 2006;AUDICANA & KENNEDY, 2008), while others have demonstrated that even inactivated parasites can cause allergic reactions (FERNÁNDEZ DE CORRES et al, 1996;DEL REY MORENO et al, 2006;VIDACEK et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Morphological and molecular diagnosis of Pseudoterranova decipiens (sensu stricto) (Anisakidae) in imported cod sold in Brazil

Mafra

Mantovani

Borges³

et al. 2015

Rev. Bras. Parasitol. Vet.

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An anisakid nematode larva found in cod sold in the state of Minas Gerais, Brazil was studied by light and scanning electron microscopy and by a molecular approach. Mitochondrial cytochrome c-oxidase subunit 2 (mtDNA cox-2), 28S rRNA and ITS1, 5.8S and ITS2 regions were amplified using the polymerase chain reaction and sequenced to evaluate the phylogenetic relationships of the larva. The genetic profile confirmed that this larva belongs to the species Pseudoterranova decipiens (sensu stricto). This is the first molecular and ultrastructural study of Pseudoterranova decipiens (sensu stricto) in imported cod sold in Brazil. The health implications of these findings are discussed.Keywords: Anisakiasis, codworm, food safety, public health. ResumoUma larva de Nematoda anisakídeo encontrada em bacalhau comercializado no Estado de Minas Gerais, Brasil foi estudada por microscopias de luz e eletrônica de varredura e por uma abordagem molecular. As regiões da subunidade 2 da citocromo c-oxidase mitocondrial (mtDNA cox-2), 28S rRNA e ITS1, 5.8S e ITS2 foram amplificadas usando a reação em cadeia da polimerase e sequenciadas para avaliar as relações filogenéticas da larva. O perfil genético confirmou que esta larva pertence à espécie Pseudoterranova decipiens (sensu stricto). Esse é o primeiro estudo molecular e ultraestrutural de Pseudoterranova decipiens (sensu stricto) de bacalhau importado vendido no Brasil. As implicações destes resultados para a saúde são discutidas.Palavras-chave: Anisakíase, bacalhau, segurança alimentar, saúde pública.

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Anaphylaxis withAnisakis simplexin the Gastric Mucosa

Cited by 73 publications

References 3 publications

Emerging helminth zoonoses

Emerging helminth zoonoses

Purification and Cloning of an Apoptosis-Inducing Protein Derived from Fish Infected with Anisakis simplex, a Causative Nematode of Human Anisakiasis

Morphological and molecular diagnosis of Pseudoterranova decipiens (sensu stricto) (Anisakidae) in imported cod sold in Brazil

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