Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation

Rönnau, Andrea C.; Wulferink, Marty; Gleichmann, Ernst; Unver, Ethem; Ruzicka, Thomas; Krutmann, Jean; Grewe, Markus

doi:10.1046/j.1365-2133.2000.03843.x

Cited by 50 publications

(27 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17,18 An anaphylactic reaction to an acetaminophen tablet was traced to its PVP ingredient. 16 However, our cases would be more consistent with a type IV, cell-mediated response, rather than a type I, an anaphylactic one. Materials other than PVP are also present in the hydrophilic coating.…”

Section: Discussionmentioning

confidence: 73%

“…Allergic reactions to PVP have been reported. [16][17][18] Aside from its use in catheter technology, PVP has many applications-for example, as a thickening and emulsifying agent in toothpastes, shampoos, contact lens solutions, and gel and tablet formulations. In combination with iodine, it forms the polyvinylpyrrolidone-iodine solution better known as Betadine (Betadine Microbicides, Stamford, Connecticut).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Foreign Body Emboli following Cerebrovascular Interventions: Clinical, Radiographic, and Histopathologic Features

Shapiro¹,

Ollenschleger²,

Baccin³

et al. 2015

AJNR Am J Neuroradiol

113

View full text Add to dashboard Cite

SUMMARY:Foreign material emboli following cerebral, cardiac, and peripheral catheterizations have been reported since the mid-1990s. Catheter coatings have been frequently implicated. The most recent surge of interest in this phenomenon within the neurointerventional community is associated with procedures using flow-diversion devices for the treatment of cerebral aneurysms. Following coil-supported Pipeline embolization in 4 cases and stent-supported coiling in 1, 5 patients developed multiple subcentimeter enhancing lesions, usually with surrounding edema and variable magnetic susceptibility in the vascular territories of the treated aneurysms. Conventional angiography findings were unrevealing. Laboratory work-up showed mild CSF protein elevation with no leukocytosis. Brain biopsy in 2 cases revealed granulomatous angiitis encasing foreign material, identical in stain appearance to a polyvinylpyrrolidone catheter coating. Corticosteroid administration typically produced clinical improvement. A heterogeneous radiographic and clinical course was noted, with rise and fall in the number of enhancing lesions in 2 patients and persistence in others. The etiology may be related to widespread adoption of increasingly sophisticated catheterization techniques.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Foreign Body Emboli following Cerebrovascular Interventions: Clinical, Radiographic, and Histopathologic Features

Shapiro¹,

Ollenschleger²,

Baccin³

et al. 2015

AJNR Am J Neuroradiol

113

View full text Add to dashboard Cite

show abstract

“…[12][13][14][15][16][17][18][19][20][21]. PVP has high chemical stability, good film forming properties and adherence to different substrates and, at the same time, low toxicity and complexing ability.…”

Section: Introductionmentioning

confidence: 99%

Relaxational study of poly(vinylpyrrolidone-co-butyl acrylate) membrane by dielectric and dynamic mechanical spectroscopy

Redondo-Foj¹,

Carsí²,

Ortiz-Serna³

et al. 2013

J. Phys. D: Appl. Phys.

View full text Add to dashboard Cite

A poly(vinylpyrrolidone-co-butyl acrylate) (60VP-40BA) membrane has been synthesized as a tractable and hydrophilic material, obtaining a water swelling percentage around 60%. An investigation of molecular mobility by means of Differential Scanning Calorimetry (DSC), Dynamic Mechanical Analysis (DMA) and Broadband Dielectric Relaxation Spectroscopy (DRS) has been fulfilled in the dry membrane. Dielectric and viscoelastic relaxation measurements have been carried out on the 60VP-40BA sample at several frequencies between -150ºC to 150ºC .The dielectric spectrum shows several relaxation processes labelled as γ, β and α in increasing order of temperature, whereas in the mechanical spectrum only the β and α relaxation processes are completely defined. In the dielectric measurements, conductive contributions overlap the α-relaxation. The apparent activation energies have similar values for the β-relaxation in both, the mechanical and the dielectric measurements. The β process is related to the local motions of the pyrrolidone group and the γ process is connected with the butyl units motions, both located in the side chains of the polymer.

show abstract

“…On the other hand, PVPP removes also quercitin (Laborde et al 2006) and resveratrol (Threlfall et al 1999), representing components that bring health benefit associated with moderate wine consumption (Castellari et al 1998). Furthermore, PVPP is contemporaneously reported as Generally Recognized as Safe (GRAS) approved for many uses by FDA, even if there have been documented cases of allergic reactions to polyvinylpyrrolidone (Ronnau et al 2000;Adachi et al 2003;Yoshida et al 2008).…”

Section: Possible Presence Of Exogenous Proteins (Ep) In Wine Could Ementioning

confidence: 99%

Hidden exogenous proteins in wine: problems, methods of detection and related legislation - a review

Rizzi¹,

Mainente²,

Pasini³

et al. 2016

Czech J. Food Sci.

View full text Add to dashboard Cite

Rizzi C., Mainente F., Pasini G., Simonato B. (2016): Hidden exogenous proteins in wine: problems, methods of detection and related legislation -a review. Czech J. Food Sci., 34: 93-104.Fining agents are commonly used in the winemaking process to clarify and stabilise wines. They have different origins (animal, vegetal or mineral) and are added to wines in order to remove specifically undesirable compounds that are discarded. Fining agents should not be present in the final product but their possible persistence, as well as other exogenous residual proteins such as the enzymes utilised in winemaking, cannot be excluded for sure. The principal concern about the presence of exogenous residual proteins is the health of allergic subjects. Nevertheless, the respect of religious creed or other practice of living of the consumer must be considered as well. In the present review we itemise the proteins used in winemaking and possible drawbacks of their permanence in the final products and the related risks, depict the status of the art of the studies performed about the detection of exogenous proteins, and describe the wine labelling laws adopted in different countries to avoid the drawbacks associated with these hidden substances.

show abstract

Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation

Cited by 50 publications

References 7 publications

Foreign Body Emboli following Cerebrovascular Interventions: Clinical, Radiographic, and Histopathologic Features

Foreign Body Emboli following Cerebrovascular Interventions: Clinical, Radiographic, and Histopathologic Features

Relaxational study of poly(vinylpyrrolidone-co-butyl acrylate) membrane by dielectric and dynamic mechanical spectroscopy

Hidden exogenous proteins in wine: problems, methods of detection and related legislation - a review

Contact Info

Product

Resources

About