Anaphylaxis to Intravenous Ranitidine in a Child

Mori, Francesca; Barni, Simona; Pecorari, Lisa; Sarti, Lucrezia; Pucci, Neri; Novembre, Elio

doi:10.1159/000398814

Cited by 5 publications

(3 citation statements)

References 9 publications

(10 reference statements)

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“…Hypersensitivity reactions are unusual, most of them are immediate type reactions, usually expressed as mild manifestations such as pruritus or acute maculopapular eruptions without other systemic symptoms [17,18]. Nonetheless, severe reactions such anaphylaxis or angioedema [15][16][17] have been reported.…”

Section: Discussionmentioning

confidence: 99%

Maculopapular delayed exanthema due to ranitidine

Hernández¹,

González²,

Vidal³

et al. 2020

Ann Dermatol Res

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Ranitidine is a widely used drug in Europe and its intake is usually well tolerated. Hypersensitivity reactions due to ranitidine are uncommon. The immediate mild reactions type are the most prevalent. In some special cases a delayed type reaction such as contact dermatitis or severe reactions with systemic involvement have been reported. In the present paper, a case report of a 78-year old patient who experienced a maculopapular eruption after 7 days of oral treatment with ranitidine is described. Patch tests were performed twice with ranitidine with positive results confirming the diagnosis. In order to discard a double sensitization and a possible cross-reactivity phenomenon, patch test was performed once with famotidine, with a negative result. This is the first maculopapular exanthema reported as type IV hypersensitivity reaction to ranitidine confirmed by patch testing. Moreover, there are only two reported cases showing a double sensitization to ranitidine and to other H2-receptor antagonists by patch testing after a delayed reaction due to ranitidine, the other being H2-receptor antagonists involving cimetidine and nizatidine, not famotidine.

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Section: Discussionmentioning

confidence: 99%

Maculopapular delayed exanthema due to ranitidine

Hernández¹,

González²,

Vidal³

et al. 2020

Ann Dermatol Res

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“…This study demonstrates comprehensive data regarding ranitidine‐induced anaphylaxis including clinical features, SPT results, cross‐reactivity, and provocation test results. Several case studies on ranitidine‐induced anaphylaxis have been reported in Italy , India , Germany , Spain , France , the UK , Japan , Turkey , Tunisia , as well as in Korea . The number of published reports on anaphylaxis patients was highest among the Korean population.…”

Section: Discussionmentioning

confidence: 99%

Ranitidine‐induced anaphylaxis: clinical features, cross‐reactivity, and skin testing

Park

Pai

Song³

et al. 2016

Clin Experimental Allergy

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“…The results of all the prick and intradermal tests performed with latex and drugs other than paracetamol were negative. 1,[4][5][6] The results of a prick test with paracetamol and an intradermal test at 1/1,000 concentration were negative as well. However, anaphylaxis developed in the form of crampy abdominal pain, headache, restlessness, and consecutive coughs 1 min after an intradermal test with a paracetamol concentration of 0.1 mg/mL (1/100 concentration).…”

Section: Case Presentationmentioning

confidence: 99%