Anaphylaxis to Drugs, Biological Agents, and Vaccines

Shah, Ruchi H; Kuder, Margaret; Lang, David M.

doi:10.1016/j.iac.2021.10.001

Cited by 4 publications

(3 citation statements)

References 109 publications

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“…Adjuvants and other vaccine components, such as preservatives and antibiotics, rather than the active ingredient itself usually trigger allergic reactions to vaccines [ 189 ]. These reactions are considered idiosyncratic and may manifest as hives, rashes, swelling, or itching in response to various vaccines, including the measles, mumps, and rubella (MMR) vaccine; the flu vaccine; and the chickenpox vaccine [ 190 , 191 ]. Recently, for the COVID-19 vaccine, in addition to the common effects, some individuals have reported more serious side effects, including allergic reactions, myocarditis (inflammation of the heart muscle), and thrombosis (blood clot formation) [ 192 , 193 ].…”

Section: Vaccines and Adverse Reactions After Immunizationmentioning

confidence: 99%

Pharmacovigilance in Vaccines: Importance, Main Aspects, Perspectives, and Challenges—A Narrative Review

Hodel,

Fiuza,

Conceição

et al. 2024

Pharmaceuticals

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Pharmacovigilance plays a central role in safeguarding public health by continuously monitoring the safety of vaccines, being critical in a climate of vaccine hesitancy, where public trust is paramount. Pharmacovigilance strategies employed to gather information on adverse events following immunization (AEFIs) include pre-registration data, media reports, clinical trials, and societal reporting. Early detection of AEFIs during clinical trials is crucial for thorough safety analysis and preventing serious reactions once vaccines are deployed. This review highlights the importance of societal reporting, encompassing contributions from community members, healthcare workers, and pharmaceutical companies. Technological advancements such as quick response (QR) codes can facilitate prompt AEFI reporting. While vaccines are demonstrably safe, the possibility of adverse events necessitates continuous post-marketing surveillance. However, underreporting remains a challenge, underscoring the critical role of public engagement in pharmacovigilance. This narrative review comprehensively examines and synthesizes key aspects of virus vaccine pharmacovigilance, with special considerations for specific population groups. We explore applicable legislation, the spectrum of AEFIs associated with major vaccines, and the unique challenges and perspectives surrounding pharmacovigilance in this domain.

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Section: Vaccines and Adverse Reactions After Immunizationmentioning

confidence: 99%

Pharmacovigilance in Vaccines: Importance, Main Aspects, Perspectives, and Challenges—A Narrative Review

Hodel,

Fiuza,

Conceição

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…In addition to respiratory reactions in patients with ASAexacerbated respiratory disease (AERD), ASA and NSAIDs may elicit cutaneous reactions in patients with NSAIDexacerbated cutaneous disease (NECD) and NSAID-induced urticaria angioedema (NIUA), each occurring via cyclooxygenase-1 inhibition, and may also provoke single-drug NSAID-induced urticaria, angioedema, or anaphylaxis (SNIUAA). 4 The characteristics of NECD, NIUA, and SNIUAA are displayed in Table I. Tolerance can routinely be induced to ASA in AERD.…”

mentioning

confidence: 99%

“…Aspirin/NSAID sensitivity syndromes Aspirin-exacerbated respiratory disease; COX-1, cyclooxygenase-1; N/A, not applicable; NECD, nonsteroidal anti-inflammatory drugeexacerbated cutaneous disease; NIUA, nonsteroidal anti-inflammatory drugeinduced urticaria/angioedema; NSAID, nonsteroidal anti-inflammatory drug; SNIUAA, single NSAID-induced urticaria, angioedema, and/or anaphylaxis. Adapted from Shah et al4 Reproduced with permission.…”

mentioning

confidence: 99%