Anaphylaxis rates associated with COVID-19 vaccines are comparable to those of other vaccines

Maltezou, Helena C.; Anastassopoulou, Cleo; Hatziantoniou, Sophia; Poland, Gregory A.; Tsakris, Athanasios

doi:10.1016/j.vaccine.2021.11.066

Cited by 48 publications

(63 citation statements)

References 16 publications

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“…However, most side effects have been mild or moderate and improved within a few days of vaccination [ 29 , 30 ]. In addition, anaphylaxis rates associated with COVID-19 vaccines were comparable to those of other vaccines [ 31 ]. Even though previous studies have claimed the safety of being vaccinated for COVID-19 during pregnancy [ 32 , 33 ], some of the respondents avoided COVID-19 vaccination due to a pregnancy status [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Citizen Stance towards Mandatory COVID-19 Vaccination and Vaccine Booster Doses: A Study in Colombia, El Salvador and Spain

et al. 2022

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The infections and deaths resulting from Coronavirus Disease 2019 (COVID-19) triggered the need for some governments to make COVID-19 vaccines mandatory. The present study aims to analyze the position of 3026 adults in Colombia, El Salvador, and Spain regarding the possibility of making COVID-19 vaccine mandatory and the intention to be vaccinated with the booster or possible successive doses. Data from an online survey conducted from August to December 2021 among a non-representative sample of Spanish-speaking countries were collected. Multinomial Logistic Regression Models were used. A total of 77.4% of Colombians were in favor of mandatory vaccination compared to 71.5% of Salvadorians and 65.4% of Spaniards (p < 0.000). Women and people over 65 years of age were the groups most in favor of making the vaccine mandatory (p < 0.000). A total of 79.4% said they had received a third dose or would intend to receive the third dose or future doses, if necessary, compared with 9.4% who expressed doubts and 9.9% who refused to be vaccinated or did not intend to be vaccinated. Among the measures that could be taken to motivate vaccination, 63.0% and 60.6% were in favor of requiring a negative test to enter any place of leisure or work, respectively, compared to 16.2% in favor of suspension from work without pay. The acceptance of mandatory vaccination and of third or future doses varies greatly according to sociodemographic characteristics and work environment. As such, it is recommended that policy makers adapt public health strategies accordingly.

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Section: Discussionmentioning

confidence: 99%

Citizen Stance towards Mandatory COVID-19 Vaccination and Vaccine Booster Doses: A Study in Colombia, El Salvador and Spain

et al. 2022

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“…The authors reported an overall lower risk of serious AEs following mRNA vaccines compared to influenza vaccines, and 103 (0.5%) deaths out of 18,755 COVID-19 vaccine-related AEs [compared to 104 (0.4%) deaths out of 27,895 influenza vaccine-related AEs] ( 50 ). Another study analyzed data from two passive surveillance systems, VAERS and European EudraVigilance, to compare the reporting rates of anaphylaxis, a severe, potentially life-threatening allergic reaction, between COVID-19 vaccines and other vaccines ( 51 ). The authors found that COVID-19 vaccines ranked fifth in reported anaphylaxis rates, behind rabies, tick-borne encephalitis, measles-mumps-rubella-varicella, and human papillomavirus vaccines (70.77, 20, 19.8, and 13.65 cases per 1,000,000 vaccine doses, respectively).…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Comparison of Adverse Events of Coronavirus Disease 2019 Vaccines Reported to the United States Vaccine Adverse Event Reporting System Between 14 December 2020 and 8 October 2021

2022

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BackgroundThis study assessed and compared the frequency and type of adverse events (AEs) of the Pfizer-BioNTech, Moderna, and Janssen coronavirus disease 2019 (COVID-19) vaccines reported in the Vaccine Adverse Event Reporting System (VAERS).MethodsA retrospective analysis examined VAERS reports between 14 December 2020 and 8 October 2021 and focused on AE reports related to COVID-19 vaccines and AE outcomes [e.g., emergency room (ER) visits after being vaccinated, hospitalization, prolongation of existing hospitalization, life-threatening events, disability, birth defect, and death]. Reporting odds ratios (RORs) and Breslow-Day statistics were used to compare AE reporting between COVID-19 and non-COVID vaccines and between individual COVID-19 vaccines.ResultsA total of 604,157 AEs of COVID-19 vaccines were reported, including 43.51% for the Pfizer-BioNTech vaccine, 47.13% for the Moderna vaccine, and 9.12% for the Janssen COVID-19 vaccine. About 12.56% of patients visited ER after being vaccinated, 5.96% reported hospitalization, and 1.52% reported life-threatening events. Among the number of death cases (n = 7,674; mean age = 73), 2,025 patients (26.39%) had hypertension and 1,237 (16.12%) patients had cancer. RORs between COVID-19 vaccines and non-COVID vaccines identified increased ROR in ER visits, hospitalization, and life-threatening events. The results of the Breslow-Day statistics indicated heterogeneities between the disproportionality of reports across the four serious AE outcomes (i.e., ER visits, hospitalization, life-threatening events, and disability) between individual COVID-19 vaccines.ConclusionMost current VAERS reports showed that the most commonly reported AEs of COVID-19 vaccines were mild. Cases with a mortality outcome tended to occur in older adults with underneath conditions. Close ongoing surveillance in the safety of COVID-19 vaccines is critical and will inform the use of individual COVID-19 vaccines. Given the known limitations associated with the passive spontaneous reporting system, such as VAERS, our findings need to be further assessed and verified through longitudinal, large healthcare data systems.

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“… 1 , 2 , 3 Recently, we demonstrated that anaphylaxis rates associated with COVID‐19 vaccines are within the range of those observed earlier with other vaccines, as indicated by passive reporting systems. 4 Herein, we aimed to comparatively assess the incidence and potential underlying causes of the most common allergic reactions post‐COVID‐19 vaccination in Europe and the United States (US). To our knowledge, such a comparison has not been performed before.…”

Section: Figurementioning

confidence: 99%

Comparative assessment of allergic reactions to COVID‐19 vaccines in Europe and the United States

Hatziantoniou

Anastassopoulou

Lampropoulou

et al. 2022

Allergy

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Anaphylaxis rates associated with COVID-19 vaccines are comparable to those of other vaccines

Cited by 48 publications

References 16 publications

Citizen Stance towards Mandatory COVID-19 Vaccination and Vaccine Booster Doses: A Study in Colombia, El Salvador and Spain

Citizen Stance towards Mandatory COVID-19 Vaccination and Vaccine Booster Doses: A Study in Colombia, El Salvador and Spain

Characteristics and Comparison of Adverse Events of Coronavirus Disease 2019 Vaccines Reported to the United States Vaccine Adverse Event Reporting System Between 14 December 2020 and 8 October 2021

Comparative assessment of allergic reactions to COVID‐19 vaccines in Europe and the United States

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