Anaphylaxis induced by hydroxyethyl starch during general anesthesia -A case report-

Kim, Hyun Jee; Kim, Sae Young; Oh, Min Ju; Kim, Jin Mo

doi:10.4097/kjae.2012.63.3.260

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…Allergic reactions to PEG, polysorbate 80, and hydroxyethylated starch solution, but not to POEPOPG, have been reported . We present here the first case of anaphylaxis showing cross‐reactivity with PEG analogues, including POEPOPG and hydroxyethyl starch.…”

Section: Discussionmentioning

confidence: 77%

A case of anaphylaxis caused by polyethylene glycol analogues

et al. 2013

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PEGs and polysorbates are found in many pharmaceuticals, cosmetics, and foods (1, 2). We report the first patient with anaphylaxis caused by PEGs and polysorbate 80 that were cross-reactive with hydroxyethyl starch.A 33-year-old man had undergone surgery for lumbar disc herniation. He went into anaphylactic shock a few minutes after the application of povidone-iodine gel to the dead space resulting from the surgery. He was successfully treated with intravenous corticosteroids and adrenaline. He reported a history of wheezing after using shampoo containing phenothirin. We performed prick tests with the constituents of the povidone-iodine gel and the phenothirin shampoo. A negative saline control and a positive histamine (10 mg/ml) control test were included. The positive wheal was 7 × 5 mm, and the negative

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Section: Discussionmentioning

confidence: 77%

A case of anaphylaxis caused by polyethylene glycol analogues

et al. 2013

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“…This is the case of dextran 67,68 and hydroxyethyl starch, 69,70 both used as plasma volume expanders. Polymeric glucosebased pharmaceutical products have been reported to induce allergic reactions, including anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…Polymeric glucosebased pharmaceutical products have been reported to induce allergic reactions, including anaphylaxis. This is the case of dextran 67,68 and hydroxyethyl starch, 69,70 both used as plasma volume expanders. Concerning to dextrin, it is being clinically used as a PD solution (icodextrin).…”

Section: Discussionmentioning

confidence: 99%

In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes

Pereira

Fraga

Maltez

et al. 2019

J Biomedical Materials Res

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The worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic‐based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels (HGs) to produce injectable/moldable SBSs. Dextrin, a low‐molecular‐weight carbohydrate, was used to develop a fully resorbable and injectable HG. It was first oxidized with sodium periodate and then cross‐linked with adipic acid dihydrazide. The in vivo biocompatibility and safety of the dextrin‐based HG was assessed by subacute systemic toxicity and skin sensitization tests, using rodent models. The results showed that the HG did not induce any systemic toxic effect, skin reaction, or genotoxicity, neither impaired the bone repair/regeneration process. Then, the HG was successfully combined with granular bone substitute, registered as Bonelike (250–500 μm) to obtain a moldable/injectable SBS, which was implanted in tibial fractures in goats for 3 and 6 weeks. The obtained results showed that HG allowed the stabilization of the granules into the defect, ensuring effective handling, and molding properties of the formulation, as well as an efficient cohesion of the granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1678–1689, 2019.

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“…Hydroxyethyl starch compounds have been reported as anaphylaxis etiologic agents [87,88], and investigation should include skin tests. The role of IgM and IgG in reactions mediated by these compounds remains uncertain [89].…”

Section: Colloidsmentioning

confidence: 99%

Perioperative Anaphylaxis

Galvão

Giavina‐Bianchi

Castells

2014

Curr Allergy Asthma Rep

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Perioperative anaphylaxis is a life-threatening condition with an estimated prevalence of 1:3,500 to 1:20,000 procedures and a mortality rate of up to 9 %. Clinical presentation involves signs such as skin rash, urticaria, angioedema, bronchospasm, tachycardia, bradycardia, and hypotension. Prompt recognition and treatment is of utmost importance to the patient's prognosis, since clinical deterioration can develop rapidly. Epinephrine is the main treatment drug, and its use should not be postponed, since delayed administration is associated with increased mortality. Elevated levels of serum tryptase help to confirm the diagnosis. The main agents involved in IgE-mediated perioperative anaphylaxis are neuromuscular blocking agents, latex, antibiotics, hypnotics, opioids, and colloids. Specific investigation should be conducted 4 to 6 weeks after the reaction and relies on skin tests, serum-specific IgE, and challenge procedures. This review aims to discuss the main aspects of perioperative anaphylaxis: risk factors, diagnosis, treatment, culprit agents, specific investigation, and preventive measures.

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Anaphylaxis induced by hydroxyethyl starch during general anesthesia -A case report-

Cited by 9 publications

References 11 publications

A case of anaphylaxis caused by polyethylene glycol analogues

A case of anaphylaxis caused by polyethylene glycol analogues

In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes

Perioperative Anaphylaxis

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