Anaphylaxis induced by exercise and wine

García-Robaina, José Carlos; Torre‐Morín, F. De La; Sánchez‐Machín, Inmaculada; Sánchez‐Monge, Rosa; Barber, Domingo; Lombardero, M.

doi:10.1034/j.1398-9995.2001.00071.x

Cited by 23 publications

(10 citation statements)

References 5 publications

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“…A possible explanation is that conventional challenges performed in a clinical setting may not result in a reduction in forced expiratory volume in 1 s (FEV 1 ) in most wine-sensitive asthmatic subjects. Anec-dotal data from our laboratory and from others are consistent with the hypothesis that cofactors play an important role in wine sensitivity [7,8]. Thus, some individuals may react to wine only when their asthma has been aggravated by exposure to other irritants or triggers in the environment, or conversely, wine consumption may increase reactivity to other irritants or triggers.…”

Section: Introductionsupporting

confidence: 86%

Changes in bronchial hyperresponsiveness following high‐ and low‐sulphite wine challenges in wine‐sensitive asthmatic patients

Vally

Thompson

Misso

2007

Clin Experimental Allergy

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Although changes in BHR, in the absence of reductions in FEV(1), were observed in some asthmatic patients following wine challenge, these changes were not consistent with a single aetiology. Consequently, this study did not support a major role for the sulphite additives in wine-induced asthmatic responses in the patients studied. The aetiology of wine-induced asthma is likely to be complex and appears to vary among individuals who are sensitive to these drinks.

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Section: Introductionsupporting

confidence: 86%

Changes in bronchial hyperresponsiveness following high‐ and low‐sulphite wine challenges in wine‐sensitive asthmatic patients

Vally

Thompson

Misso

2007

Clin Experimental Allergy

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“…Most patients reported with grape allergy did not tolerate any grape species, wine or raisins [3,4,5,6,7,8]. Only 1 patient seems to have a grape allergy specific to a certain Americana blue grape but tolerance to other grapes [3].…”

Section: Discussionmentioning

confidence: 99%

“…Grapes grown in temperate and subtropical areas on all continents are widely consumed as fresh fruit, juice and wine. However, allergy to grapes has been rarely reported [3,4,5,6,7,8]. In a recent study, endochitinase 4, LTP Vit v 1 (accession No.…”

Section: Introductionmentioning

confidence: 99%

Wine Anaphylaxis in a German Patient: IgE-Mediated Allergy against a Lipid Transfer Protein of Grapes

Schäd

Trcka

Vieths

et al. 2005

Int Arch Allergy Immunol

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Background: IgE-mediated allergy to grapes has very rarely been reported in patients from the Mediterranean area. Recently, endochitinase 4 and a lipid transfer protein (LTP) have been identified as major allergens in grape-allergic patients who do not have an associated pollinosis. The purpose of this case study was to identify the allergens responsible for severe anaphylactic reactions after consumption of wine, fresh grapes and raisins in a German patient. Methods: Prick-to-prick tests and the basophil activation test (BAT) were performed to confirm allergy. Specific IgE was further analyzed by immunoblotting and inhibition tests for the determination of crossreactivity. The IgE-binding protein was subjected to N-terminal microsequencing. Results: Prick-to-prick tests were positive to fresh and cooked white and blue grapes, to raisins, to white and red wine, and to grape extract. Specific IgE against grapes (f259) was 2.43 kU/l (class 2). The BAT showed specific IgE-mediated activation of basophils after stimulation with grape extract. IgE binding to a 15-kDa protein was completely inhibited by pre-incubation with recombinant cherry LTP Pru av 3. N-terminal sequencing identified this 15-kDa protein as grape LTP Vit v 1. Conclusion: Our data show that sensitization to LTP can occur outside the Mediterranean area causing severe fruit allergy without association to pollinosis.

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“…Grape allergy cases are most often displayed as an OAS [177,178] ; however, more severe manifestations, including asthma, exercise -induced anaphylaxis [179,180] , and anaphylactic shock [181,182] have also been reported. Grape allergy cases are most often displayed as an OAS [177,178] ; however, more severe manifestations, including asthma, exercise -induced anaphylaxis [179,180] , and anaphylactic shock [181,182] have also been reported.…”

Section: Grape Allergymentioning

confidence: 99%