Anaphylaxis from cow's milk casein

Tabar, A. I.; Álvarez, Miguel; Echechipía, S.; Acero, S.; Be, García; Olaguíbel, J M

doi:10.1111/j.1398-9995.1996.tb00097.x

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…However, some studies have indicated that children with CMPA have higher concentrations of specific IgE antibody to proteins comprising the whey fractions of milk [8] while IgE directed to the proteins in the casein fraction appeared to be dominant in older children and adults with CMPA [9,10].…”

Section: Introductionmentioning

confidence: 99%

Cow's milk protein‐specific IgE concentrations in two age groups of milk‐allergic children and in children achieving clinical tolerance

Sicherer

Sampson

1999

Clin Experimental Allergy

129

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Section: Introductionmentioning

confidence: 99%

Cow's milk protein‐specific IgE concentrations in two age groups of milk‐allergic children and in children achieving clinical tolerance

Sicherer

Sampson

1999

Clin Experimental Allergy

129

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“…The risk of serious and life-threatening allergic reactions associated with the consumption of specific proteins in highly allergenic foods such as peanuts [14], milk [15], eggs [16], wheat [17] and soybeans [18] is well recognized as an important health issue for a small percentage of individuals in the population. While the prevalence of food allergy is not precisely known, estimates from various clinical studies and surveys indicate that 1–3% of adults and 6–8% of children experience some food-allergic reactions with an overall prevalence of up to 4% of the US population having IgE-mediated food allergies [19].…”

Section: Rationale For the Allergenicity Assessment Processmentioning

confidence: 99%

Assessing Genetically Modified Crops to Minimize the Risk of Increased Food Allergy: A Review

Goodman

Hefle

Taylor

et al. 2005

Int Arch Allergy Immunol

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The first genetically modified (GM) crops approved for food use (tomato and soybean) were evaluated for safety by the United States Food and Drug Administration prior to commercial production. Among other factors, those products and all additional GM crops that have been grown commercially have been evaluated for potential increases in allergenic properties using methods that are consistent with the current understanding of food allergens and knowledge regarding the prediction of allergenic activity. Although there have been refinements, the key aspects of the evaluation have not changed. The allergenic properties of the gene donor and the host (recipient) organisms are considered in determining the appropriate testing strategy. The amino acid sequence of the encoded protein is compared to all known allergens to determine whether the protein is a known allergen or is sufficiently similar to any known allergen to indicate an increased probability of allergic cross-reactivity. Stability of the protein in the presence of acid with the stomach protease pepsin is tested as a risk factor for food allergenicity. In vitro or in vivo human IgE binding are tested when appropriate, if the gene donor is an allergen or the sequence of the protein is similar to an allergen. Serum donors and skin test subjects are selected based on their proven allergic responses to the gene donor or to material containing the allergen that was matched in sequence. While some scientists and regulators have suggested using animal models, performing broadly targeted serum IgE testing or extensive pre- or post-market clinical tests, current evidence does not support these tests as being predictive or practical. Based on the evidence to date, the current assessment process has worked well to prevent the unintended introduction of allergens in commercial GM crops.

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“…IgE antibodies binding to casein appeared to be dominant in older children and adults with CMA. 11,12 Children who have persistent CMA have significantly elevated levels of casein-specific IgE antibodies compared with younger children. 13…”

mentioning

confidence: 99%

Identification of IgE- and IgG-binding epitopes on αs1-casein: Differences in patients with persistent and transient cow's milk allergy

Chatchatee

Järvinen

Bardina

et al. 2001

Journal of Allergy and Clinical Immunology

271

179

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Anaphylaxis from cow's milk casein

Cited by 8 publications

References 9 publications

Cow's milk protein‐specific IgE concentrations in two age groups of milk‐allergic children and in children achieving clinical tolerance

Cow's milk protein‐specific IgE concentrations in two age groups of milk‐allergic children and in children achieving clinical tolerance

Assessing Genetically Modified Crops to Minimize the Risk of Increased Food Allergy: A Review

Identification of IgE- and IgG-binding epitopes on αs1-casein: Differences in patients with persistent and transient cow's milk allergy

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