Anaphylaxis effect and substance basis of honeysuckle extract

Feng, Yukuan; Qin, Guozhao; Jing, Zhongxu; Wang, Yanhong; Zhou, Yanyan

doi:10.1016/j.chmed.2021.04.013

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…Poria polaris extract was found to ameliorate neurotransmitter and circadian rhythm disorders in CUMS rats by regulating circadian genes Arntl, Per1, Per2, Per3, and Nr1d1, leading to improved expression levels. [39] Paeoniflorin, a monoterpenoid glycoside compound derived from the roots of Paeonia lactiflora, exhibits antioxidant, anti-inflammatory, anti-fibrotic, and neuroprotective effects. [40] Studies have shown that depression model rats exhibit disrupted rhythms of clock gene expression in the hippocampus and administration of paeoniflorin significantly improves the changes in clock and Bmal1 gene expression rhythms, thereby exerting an antidepressant effect.…”

Section: Active Ingredients In Tcmmentioning

confidence: 99%

“…Regulating the expression of circadian rhythm genes Per2 and Cry2 [36] β-Asarone CUMS SPF male SD rats 12.5, 25 g/kg Regulation of the expression of circadian rhythm gene Per1 in the brain region of [38] Poria polaris extract CUMS SPF male SD rats 55.45 mg/mL Regulation of the expression levels of circadian rhythm genes Arntl, Per1, Per2, Per3, Nr1d1 [39] Paeoniflorin CUMS SPF male SD rats 5, 15 mg/kg Improving the Rhythmic Changes of Clock and Bmal1 Expression in Biological Clock Genes [41] Theanine Residential invasion Male ddY mice 5-100 μg/mL Regulating the circadian rhythm secretion of the HPA axis [42] Acupuncture STZ + High fat and high sugar diet SPF male SD rats Housanli, Sanyinjiao, and Baihui Downregulation of Per2 gene expression in SCN [44] Electroacupuncture CUMS SPF male SD rats Baihui and Yintang Regulating body temperature and melatonin circadian rhythm changes [46] Electroacupuncture Maternal separation Male and female Wister rats Baihui and Yintang Regulating biological clock genes Per2 and Dbp…”

Section: Dosage or Intervention Points Mechanism Involved Referencesmentioning

confidence: 99%

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Antidepressant mechanism of traditional Chinese medicine: Involving regulation of circadian clock genes

Lv,

Huang,

et al. 2024

Medicine

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Numerous studies have demonstrated an intimate relationship between circadian rhythm disorders and the development and prevention of depression. The biological clock genes, which constitute the molecular basis of endogenous circadian rhythms, hold promising prospects for depression treatment. Based on an extensive review of recent domestic and international research, this article presents a comprehensive analysis of how traditional Chinese medicine (TCM) intervenes in depression by regulating circadian rhythms. The findings indicate that TCM exerts its antidepressant effects by targeting specific biological clock genes such as Bmal1, clock, Arntl, Per1, Per2, Per3, Nr1d1, Cry2, and Dbp, as well as regulating circadian rhythms of hormone secretion. However, most current research is still confined to basic experimental studies, lacking clinical double-blind control trials to further validate these viewpoints. Furthermore, there is insufficient research on the signal transduction pathway between biological clock genes and pathological changes in depression. Additionally, further clarification is needed regarding the specific targets of TCM on the biological clock genes.

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Section: Active Ingredients In Tcmmentioning

confidence: 99%

Section: Dosage or Intervention Points Mechanism Involved Referencesmentioning

confidence: 99%

Antidepressant mechanism of traditional Chinese medicine: Involving regulation of circadian clock genes

Lv,

Huang,

et al. 2024

Medicine

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“…Honeysuckle has high nutritional value and is often used as a health care drug [2]. The main active components of honeysuckle are chlorogenic acid and isochlorogenic acid and their isomers [3]. The research showed that chlorogenic acid and isochlorogenic acid isomers had the pharmacological actions of clearing away heat and detoxification, antioxidation, and antibacteria [4].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous separation and determination of five chlorogenic acid isomers in Honeysuckle by capillary electrophoresis using self‐synthesized ionic liquid [N‐methylimidazole‐β‐cyclodextrin] [bromide] as separation selector

Xie

Hou

et al. 2022

J of Separation Science

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A simple, comprehensive, and efficient capillary electrophoresis method using a self‐synthesized ionic liquid [N‐methylimidazole‐β‐cyclodextrin] [bromide] as a separation selector was developed for the simultaneous separation and determination of five chlorogenic acid isomers (chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, isochlorogenic acid A, isochlorogenic acid B). After optimization of separation conditions, the electrolyte solution was 50 mM ammonium acetate buffer containing 0.7% (w/w) ionic liquid [N‐methylimidazole‐β‐cyclodextrin] [bromide] (pH 4.8), 15 kV of the electric field was applied at 25°C, and the detection wavelength was at 237 nm. Under the optimal separation conditions, good linearities were obtained with linear correlation coefficients of the five analytes of 0.9994–0.9998, and the limits of detection and the limits of quantification were 0.6–2.8 and 2.2–9.5 μg/ml. Excellent accuracy and precision were obtained for the five analytes. The intraday and interday precision of standards ranged from 0.5 to 1.3% and from 1.2 to 1.9%. The intraday and interday precision of samples ranged from 1.0 to 1.9% and from 1.2 to 2.6%. The sample recovery rates were between 98.0 and 101.8%. This method was successfully applied for the analysis of five components in Honeysuckle Chinese medicinal preparations. The mechanisms involved in the separation of five analytes by [N‐methylimidazole‐β‐cyclodextrin] [bromide] were discussed.

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Anaphylaxis effect and substance basis of honeysuckle extract

Cited by 2 publications

References 24 publications

Antidepressant mechanism of traditional Chinese medicine: Involving regulation of circadian clock genes

Antidepressant mechanism of traditional Chinese medicine: Involving regulation of circadian clock genes

Simultaneous separation and determination of five chlorogenic acid isomers in Honeysuckle by capillary electrophoresis using self‐synthesized ionic liquid [N‐methylimidazole‐β‐cyclodextrin] [bromide] as separation selector

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