Anaphylaxis due to liposomal amphotericin (AmBisome)

Abstract

Letters to the Editor study population (12.75%). Thus we can confirm that the presence of vaginal and cervical ulcers may be considered an additional risk factor for HIV transmission. Although our study was performed on sera belonging to women considered at risk for HIV infections, only 2% of them were certainly infected by HIV-1 and none was infected by HIV-2. This percentage is consistent with another study on an analogous sample of 100 women in February 1993 (data not shown). During the last 10 years, the war in Angola has greatly limited movement of people between Luanda province and the bordering provinces of Congo, Zaire and Zambia. Probably the low prevalence of HIV in Luanda is due to the partial isolation of the city during the spread of HIV pandemic in Sub Sahara Africa.

Nanotoxicology of an Elastin-like Polypeptide Rapamycin Formulation for Breast Cancer

“…Several clinically approved formulations, namely, liposomal doxorubicin (Doxil), liposomal amphotericin (AmBisome), and intravenous paclitaxel (Taxol), , are inflammatory through the activation of the complement system of proteins . Such immune activation may lead to a severe or even fatal condition called complement activation-related pseudoallergy (CARPA). , CARPA is used to describe hypersensitivity reactions to nanomedicines occurring in up to 45% of individuals .…”

“…73 However, the effect on clotting time was not found to be physiologically significant (prolongation ≥ 2-fold vs untreated control is considered physiologically significant). Several clinically approved formulations, namely, liposomal doxorubicin (Doxil), 57 liposomal amphotericin (AmBisome), 74 and intravenous paclitaxel (Taxol), 75,76 are inflammatory through the activation of the complement system of proteins. 77 Such immune activation may lead to a severe or even fatal condition called complement activation-related pseudoallergy (CARPA).…”

Chest Discomfort Associated with Liposomal Amphotericin B: Report of Three Cases and Review of the Literature

“…[24][25][26][27][28] Allergic reactions and anaphylaxis have been reported with amphotericin B deoxycholate as well as lipid products, thus justifying the recommendation of a l-mg test dose. ', 3 , '', 12, [29][30][31][32][33][34] Allergic reactions to amphotericin B are typically characterized by tachypnea, dyspnea, and acute bronchospasm manifested by wheezing, and may also include flushing, facial edema, and rash.'. [29][30][31][32][33][34] They often respond to treatment with intravenous diphenhydramine and hydro- [29][30][31][32][33][34] and may appear on re~hallenge.~~ None of our patients experienced bronchospasm or tachypnea, and in two of them, rechallenge with other amphotericin B preparations did not produce apparent allergic reactions.…”

First Report on Ambisome-Associated Allergic Reaction in Two Sudanese Leishmaniasis Patients

“…4,5,7,8 The documented allergic reaction to Ambisome during treatment of PKDL and ML warrants close supervision of patients, especially since Ambisome is currently considered to be a first-line treatment of leishmaniasis in several endemic regions . …”