Abstract:which are caused by mutations resulting in activation of mTOR. 5 Thus, we speculate that vemurafenib-associated gingival hyperplasia may be related to increased activation of the PI3K-mTOR pathway that potentially occurs during the course of treatment. This hypothesis is supported by the observation of gingival hyperplasia occurring relatively later on during the treatment course when resistance is expected to emerge.Our report of the second case of gingival hyperplasia in association with vemurafenib further … Show more
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