Anaphylaxis, beta blockade and the Kounis syndrome

Kounis, George N.; Hahalis, George; Kounis, Nicholas G.

doi:10.1111/j.1460-9592.2008.02560.x

Cited by 6 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, administration of the usual dose of epinephrine (the drug of choice used in anaphylaxis) in patients under the effect of beta-blockers may exaggerate coronary spasm due to unopposed activity of alpha-adrenergic receptors [17, 19]. Furthermore, beta blockers may enhance the generation and release of anaphylaxis mediators and their effects on end organs [20]. Treatment of aspirin-exacerbated respiratory disease includes the substitution of another category of antiplatelet agents, such as thienopyridines, or a desensibilization as an alternative for patients who are allergic to aspirin and need long-term therapy of aspirin for cardiovascular diseases [5].…”

Section: Discussionmentioning

confidence: 99%

Kounis syndrome induced by oral intake of aspirin: case report and literature review

Hangouche¹,

Lamliki²,

Oukerraj³

et al. 2018

Pan Afr Med J

View full text Add to dashboard Cite

The Kounis-Zavras syndrome is defined as the coincidental occurrence of acute coronary events and hypersensitivity reactions following an allergic reaction including a mast-cell degranulation of vasospastic mediators. This report describes a case of Kounis-Zavras syndrome in the setting of aspirin-induced asthma also known as Samter-Beer triad combining nasal polyps, asthma, and aspirin allergy leading to vasospasm and myocardial infarction. All physicians should be aware of The Kounis syndrome and always keep that unique clinical entity in mind to recognize it promptly and direct the therapy at suppressing the allergic reaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Kounis syndrome induced by oral intake of aspirin: case report and literature review

Hangouche¹,

Lamliki²,

Oukerraj³

et al. 2018

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…It was described in 1991, also having as variants vasospastic angina of allergic etiology, allergic myocardial infarction, and stent thrombosis -if occlusive thrombus infiltrated by eosinophils and/or mastocytes . [1][2][3] The syndrome is caused by inflammatory mediators such as histamine, platelet activating factor, arachidonic acid products, neutral proteases, cytokines, and chemokines that trigger a cascade that results in the activation of inflammatory cells. This set of mediators, in turn, feed a vicious cycle with the release of more mediators.…”

Section: Introductionmentioning

confidence: 99%

“…All of this leads to coronary vasospasm justifying its clinic of an acute coronary syndrome. 3 To date, several triggering factors of such a hypersensitivity reaction have been described and their number continues to grow. In addition, factors like medicines and food can be highlighted.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, factors like medicines and food can be highlighted. 3 Among the drugs, several classes frequently used in clinical practice are triggers of SK, such dipyrone, etomidate, beta-lactam antibiotics, trimetafan, non-steroidal anti-inflammatories, antineoplastics, contrasts, corticosteroids, antiseptics, muscle relaxants, proton pump inhibitors, thrombolytics and anticoagulants, among others. 4 Apparently, SK is not a rare syndrome, but there is little medical knowledge in general due to lost cases and undiagnosed and/or reported cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kounis Syndrome: Case Report in Goiânia/BR

Pereira¹,

Vieitas²,

Freitas³

et al. 2021

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

22-year-old male patient with no heart disease, who was given an ambulatory medication with analgesics due to an acute renal crisis. After the drug administration, the patient presented dyspnea, cyanosis, and hemoptysis. There was suspicion of anaphylactic shock, which was treated, but there was no improvement in the clinical condition. The patient was referred to the Intensive Care Unit, where tests were performed showing elevated cardiac enzymes and Immunoglobulin E and Computed Tomography of Thoracic revealed alveolar hemorrhage. He developed clinical worsening and died after sepsis. The final diagnosis was of kounis syndrome due to the hypersensitivity reaction to the analgesics introduced in the patient, generating an acute coronary syndrome (ACS). The purpose of this case report was to highlight a syndrome that is little reported because it is not part of the differential diagnosis routines of ACS, but it generates important complications.

show abstract

“…These bridges can be made by antigens of different specificities as it happens in patients during anesthesia (18). It looks likely that the more antigens an anesthetized patient is exposed to, the easier and quicker the degranulation occurs (19–22).…”

mentioning

confidence: 99%