Anaphylactoid reaction to propofol

Abstract

Summary A case of an anaphylactoid reaction following the induction of anaesthesia is reported. Subsequent intradermal testing suggested propofol to be the causative agent.

Asthma, Sedation, and the Podiatric Patient

“…Typically, propofol is cited in literature to possess bronchodilating properties thereby decreasing wheezing and reducing exacerbations of asthma in the asthmatic individual [1,3]. However, bronchospastic episodes and other reactions following propofol administration have been documented [1,[4][5][6][7][8][9][10][11][12][13][14]. Previously proposed etiologies for propofol reactions include a phenomenon related to histamine release as well as a reactionary cascade secondary to various chemical compounds found in propofol [5][6][7].…”

Histamine release during the induction of anesthesia with propofol in allergic patients: A comparison with the induction of anesthesia using midazolam-ketamine

“…Propofol has also been recommended for the induction of anesthesia in patients with asthma in other reports [23,24]. Generally, propofol is thought to be a safer intravenous anesthetic agent in regard to histamine release reactions, however, some anaphylactoid reactions have been already reported [5][6][7][8].…”

“…In previous clinical studies, propofol was suggested to have many advantages as an anesthetic induction agent because of its low incidence of allergic reaction [1][2][3][4], however, some anaphylactoid reactions have been reported with propofol including the development of weals on skin and bronchospasms [5][6][7][8].…”

Perioperative anaphylaxis

“…Of the hypnotic agents used anaphylactic reactions are more often seen with thiopental and propofol, although as a group hypnotics are a rare cause [142][143][144]. Diagnosis is by skin and intradermal testing, although a RAST method for detecting IgE to thiopentone has been described [143].…”