Anaphylactoid and adverse reactions to radiocontrast agents

Hagan, John B.

doi:10.1016/j.iac.2004.03.005

Cited by 28 publications

(24 citation statements)

References 86 publications

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“…These are both patient related, such as age, gender, atopy and accompanying atopic or nonatopic diseases, and drug related, such as dose, group or route of administration [4,6,7,8,9,10,23]. As with findings from these studies, female gender resulted in a 2-fold increase in the prevalence of CM hypersensitivity in our study.…”

Section: Discussionsupporting

confidence: 84%

“…Contrary to the common false belief about the connection between iodine and seafood allergy, there was no specific food that was associated with hypersensitivity to CMs in our study, but the number of patients with a history of food allergy was very limited [24,25]. The frequency of associated drug allergy with CM hypersensitivity is well known [8,10,13,26], as we have observed in our study. Doctor-diagnosed psychiatric disorders constituted another prominent risk factor in our study.…”

Section: Discussioncontrasting

confidence: 77%

“…The prevalence rate of CM-induced hypersensitivity reactions was first evaluated through phase II and III clinical trials and then through large-scale postmarketing surveillance studies [4,5,6]. Since the introduction of nonionic CMs into clinical practice, adverse reactions associated with CM administration have been reported less frequently [5,7,8,9,10]. A large-scale nationwide study in Japan reported that not only the prevalence of all degrees of adverse reactions to CMs but also the prevalence of severe and potentially life-threatening adverse reactions were significantly reduced with nonionic CMs [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hypersensitivity Reactions to Contrast Media: Prevalence, Risk Factors and the Role of Skin Tests in Diagnosis – A Cross-Sectional Survey

Göksel¹,

Aydın²,

Atasoy

et al. 2011

Int Arch Allergy Immunol

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Background: Hypersensitivity to contrast media (CMs) may be common and serious. Aim: To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. Methods: A structured questionnaire was administered to patients who underwent computed tomography during a 1-year period. Skin tests with CMs, including skin prick tests (SPTs), intradermal tests (IDTs) and patch tests (PTs), were conducted on CM reactors (n = 24). Volunteers who tolerated CM exposure or had never been exposed to any CMs served as controls (n = 37). Results: A total of 1,131 patients (630 females and 501 males; mean age 55 ± 14.2 years) were enrolled in the study. The prevalence of historical and current CM reactors was 33/1,131 (2.92%) and 8/1,105 (0.72%), respectively. The skin was the most affected site, with mild to moderate reactions. Female gender, a history of doctor-diagnosed asthma, drug allergy, food allergy and psychiatric diseases were significant risk factors. The sensitivities of SPTs and early readings of IDTs in the diagnosis of immediate reactions were 0 and 20%, respectively, and the specificities were 94.6 and 91.4%, respectively. For early readings of IDTs, the positive predictive value (PPV) and negative predictive value (NPV) were 40 and 80%, respectively. For nonimmediate reactions, the sensitivities of delayed readings of IDTs and PTs were 14.3 and 25%, respectively; specificity was 100% for both tests. The PPV was 100% for both of these tests, and the NPVs were 85.4 and 82.4%, respectively. Conclusions: Our findings are comparable with the incidence, profile and risk factors associated with CM hypersensitivity reported previously. Skin testing with CMs has a high specificity, but its role in diagnosis is limited due to low sensitivity.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Hypersensitivity Reactions to Contrast Media: Prevalence, Risk Factors and the Role of Skin Tests in Diagnosis – A Cross-Sectional Survey

Göksel¹,

Aydın²,

Atasoy

et al. 2011

Int Arch Allergy Immunol

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“…O mecanismo destas reações pode envolver a produção e/ou liberação de histamina, serotonina, prostaglandinas, bradicinina, leucotrienos, dentre outros sistemas enzimáticos. 12,13 O colégio Americano de Radiologia (ACR-American College of Radiology) divide as reações anafilactoides em três graus de severidade: (1) Leves: sendo auto limitadas, incluindo náusea, vômito, urticária, prurido, edema cutâneo, coceira, congestão nasal, tonturas, sudorese, calafrios, espirros, conjuntivite e rinorreia; (2) Moderadas: são mais pronunciadas e requer tratamento farmacológico, incluindo urticária difusa, prurido e eritema, hipertensão ou hipotensão leve, bradicardia ou taquicardia, broncoespasmo sem ou com hipóxia, edema de laringe leve; (3) Graves: requerem tratamento hospitalar, incluindo edema facial ou difuso, eritema difuso e hipotensão grave, edema grave de laringe, broncoespasmo, arritmia grave e parada cardiorrespiratória. As reações ainda podem ser do tipo agudas, ocorrendo 30 minutos após a administração do contraste e tardias, quando aparecem após 30 minutos até sete dias após a administração.…”

Section: Métodounclassified

Avaliação das reações adversas ao uso de contrastes em exames de diagnóstico por imagem

Pozzobon

Trindade

2017

Cinergis

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“…These reactions can occur with the first dose of the drug without a need for a certain sensitization time in contrast to actual allergic reactions. Opiates, vacomycin, radiocontrast materials, aspirin and other non-steroid antiinflammatory drugs cause clinical pictures similar to urticaria, angioedema and even anaphylaxis (3,17).…”

Section: Non-allergic (Pseudo-allergic) Hypersensitivity Reactionsmentioning

confidence: 99%

Çocuklarda ilaç alerjileri

...

2012

Tpa

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Review Sum maryDrug allergy when compared with other allergic diseases can be the cause of very serious reactions and can be life-threatening if neglected. In clinical practice, a wide range of symptoms from mild urticaria to anaphylaxis can be observed so that it can mimic the symptoms of all other allergic diseases. One of the significant consequences of allergic drug reactions is the use of less effective, more expensive or more toxic drugs in the future. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Confirmatory tests, if avaliable, should be used to determine the allergic status of the patient. If these tests are not avaliable, depending on the type of clinical reaction previously demonstrated, a graded challenge or desensitization may be considered. Education of the patient and primary care physician is an important component of management. (Turk Arch Ped 2012; 47: 86-91)

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Anaphylactoid and adverse reactions to radiocontrast agents

Cited by 28 publications

References 86 publications

Hypersensitivity Reactions to Contrast Media: Prevalence, Risk Factors and the Role of Skin Tests in Diagnosis – A Cross-Sectional Survey

Hypersensitivity Reactions to Contrast Media: Prevalence, Risk Factors and the Role of Skin Tests in Diagnosis – A Cross-Sectional Survey

Avaliação das reações adversas ao uso de contrastes em exames de diagnóstico por imagem

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