Anaphylactic shock in the pertussis-vaccinated mouse

Malkiel, Saul; Hargis, Betty J.

doi:10.1016/0021-8707(52)90055-5

Cited by 50 publications

(25 citation statements)

References 12 publications

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“…There is some evidence, however, that histamine is not the sole mediator in other animal species, where it is thought that 5-hydroxytryptamine plays a more or less important role (Fink, 1956;Parratt & West, 1957). In fact, histamine antagonists have little, if any, effect on anaphylaxis in mice (Malkiel & Hargis, 1952), rats (Halpern, Liacopoulos & Perez Del Castillo, 1955;Rowley & Benditt, 1956) and rabbits (Reuse, 1949). On the other hand, reserpine and other agents which deplete 5-hydroxytryptamine stores have been found recently to protect mice against anaphylactic shock (Gershon & Ross, 1962).…”

mentioning

confidence: 99%

On the Nature of the Chemical Mediators Involved in Anaphylactic Reactions in Mice

Halpern

Neveu

Spector

1963

British Journal of Pharmacology and Chemotherapy

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The effects of mepyramine, promethazine, chlorpromazine and lysergic acid diethylamide have been compared on the capillary permeability changes of the skin, produced by histamine, by 5-hydroxytryptamine and by passive cutaneous anaphylaxis in mice. Promethazine, mepyramine and chlorpromazine can inhibit, in decreasing order of activity, the effect of histamine, whilst lysergic acid diethylamide is inactive. Lysergic acid diethylamide and chlorpromazine are equally potent inhibitors of the action of 5-hydroxytryptamine on the peripheral vascular bed, whilst mepyramine is inactive. Promethazine has intermediate activity. Passive cutaneous anaphylaxis is strongly inhibited by chlorpromazine and by promethazine. Mepyramine and lysergic acid diethylamide, each injected alone, affect only weakly the anaphylactic reaction. However, passive cutaneous anaphylaxis is almost completely abolished by the simultaneous injection of the two last antagonists. It is suggested that the anaphylactic reaction in mice is the result of simultaneous release of both mediators, histamine and 5-hydroxytryptamine, each of them strengthening the effect of the other.

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confidence: 99%

On the Nature of the Chemical Mediators Involved in Anaphylactic Reactions in Mice

Halpern

Neveu

Spector

1963

British Journal of Pharmacology and Chemotherapy

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“…The difference, however, between the well known influence of gluco corticoids on precipitine formation in the rabbit (1,5,9) and the in activity of the mineralo-corticoid DCA in this respect is certainly in teresting to note.…”

Section: Results and Conclusionmentioning

confidence: 82%

Quantitative Studies on the Production of Precipitating Antibodies in Rabbits with and without DCA Treatment

Hoene¹,

Adamkiewicz²

1953

Int Arch Allergy Immunol

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“…Relaxing ac tion of papaverine is said to be due to a drop in effective concentration of Ca in Ca-store (34). Furthermore, it is reported that in the relaxing actions of Adr and papaverine, the abolition of spike activity is observedpredominantly, and that hyperpolarization enhances inhibition of mechanical activity (36 (45). Elucidation of the action mechanism of these drugs awaits future studies.…”

Section: Effects On Antigen-antibodv Combinationmentioning

confidence: 99%

Inhibitory Action of Some Antihistaminics on the Anaphylactic Contraction in Guinea Pig's Taenia Coli

Okamura

SHIINA

1972

Jpn.J.Pharmacol

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Since Dale's report (1) on a hypothetical role of histamine in anaphylactic shock, the view that the histamine plays as an important chemical mediator in allergic reaction has been steadily supported by many investigators (2-10). Antihistaminics are now widely applied in allergy clinics to suppress the action of histamine produced endogenously by antigen-antibody reaction. The therapeutic effect of antihistaminics on allergic dis eases is believed to be ascribed to the competition with histamine on histamine-receptor (11, 12) the drugs never acting on the immunological process itself (13). It is also ac knowledged that allergic symptomes do not entirely disappear even after the administration of antihistaminics (14-16). On the other hand, it has been noted that several substances besides histamine were found to play roles in allergic shock and that antihistaminics had many pharmacological actions, in addition to antihistaminic action (17-23). Previously, Okamura (24) reported that anaphylactic contraction of taenia coli from guinea pig was dependent on the electric smooth muscle cell membrane potential. It has consequently been assumed that examination of the influence of spasmolytic drugs on membrane potential will not only have important implication for the elucidation of anaphylactic contraction, but also provede valuable clues for future study of anti-allergic drugs. In the present paper, antihistaminics were compared with adrenaline, papaverine and atro pine for the purpose of elucidating the antihistaminics' inhibitory action on anaphylactic contraction in guinea pig's taenia coli using an electrophysiological method. MATERIALS AND METHODSExperimental animals: Guinea pigs of Hartley strain, weighing 350-400 g, were maintained in the animal stock room, temperature 22-24CC and humidity 60%, and fed the standard solid diet (GC-4, Oriental Yeast Co., Ltd., Tokyo). Hartley males showing a wt gain during 4 weeks were used. Rabbits, weighing approx. 2 kg, were kept under the similar conditions. Sensitization: A 10% egg-albumin in saline solution was used as sensitizing antigen. Rabbits were sensitized by subcutaneous injection of this antigen twice a week in a dose of 2 ml. A 0.1 ml of the antigen was given intracutaneously in the foot pad once a week. The sensitization was continued for 4 weeks. Two weeks after the final sensitization, antibody titration was measured by the ring method, and when precipitin titer had

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Anaphylactic shock in the pertussis-vaccinated mouse

Cited by 50 publications

References 12 publications

On the Nature of the Chemical Mediators Involved in Anaphylactic Reactions in Mice

On the Nature of the Chemical Mediators Involved in Anaphylactic Reactions in Mice

Quantitative Studies on the Production of Precipitating Antibodies in Rabbits with and without DCA Treatment

Inhibitory Action of Some Antihistaminics on the Anaphylactic Contraction in Guinea Pig's Taenia Coli

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