Anaphylactic reactions to local anesthetics in dental practice: a nationwide French retrospective study

Hascoët, E; Mahé, Julien; Meillard, H; Cloître, Alexandra; Lesclous, Philippe

doi:10.1007/s00784-021-04139-5

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…Other amides are safer in this respect, though published data demonstrates that some cause anaphylactic shock, which was demonstrated for mepivacaine [ 38 ] and bupivacaine [ 39 ]. A French Pharmacovigilance Database System analysis revealed a twentyfold growth in the number of reports on anaphylactic reactions involving local anesthetics from 1985 to 2020, and lidocaine was reported to be the most common cause (81.49%) [ 40 ]. The leading role of lidocaine in severe HSRs and anaphylaxis development in dental practice was stated in the work by Matveev et al (2020) [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2024

Pharmaceuticals

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(1) Background: National health system databases represent an important source of information about the epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. Analysis of such databases may enhance the knowledge of healthcare professionals regarding the problem of drug-induced anaphylaxis. (2) Methods: A retrospective descriptive analysis was carried out of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) extracted from the Russian National Pharmacovigilance database (analyzed period 2 April 2019–21 June 2023). The percentage of SRsAs among SRs of drug-induced allergy (SRsDIAs) was calculated, as well as of pediatric, elderly, and fatal SrsAs. Drugs involved in anaphylaxis were assessed among total SRsAs, pediatric, and elderly SRsAs, and among fatal SRsAs. Demographic parameters of patients were assessed. (3) Results: SRsAs were reported in 8.3% of SRsDIAs (2304/27,727), the mean age of patients was 48.2 ± 15.8 years, and females accounted for 53.2% of cases. The main causative groups of drugs were antibacterials (ABs) for systemic use (44.6%), local anesthetics (20.0%), and cyclooxygenase (COX) inhibitors (10.1%). Fatal SRsAs were reported in 9.5% (218/2304) of cases, the mean age of patients was 48.0 ± 16.7 years, and females accounted for 56.4% of cases. Pediatric SRsAs accounted for 3.9% of pediatric SRsDIAs and 5.8% of all SRsAs, with a mean age of 11.8 ± 4.5 years, and females acccounted for 51.9% of cases. Elderly SRsAs accounted for 2% of elderly SRsDIAs and 2.8% of all SRsAs, and the mean age was 73.0 ± 5.3 years, and females accounted for 43.5% of cases. ABs caused 40% of SRsAs in the elderly, 42.9% in children, and 50% of fatal SRsAs. (4) Conclusions: Our study revealed a relatively high proportion of anaphylaxis among SRs of drug-induced allergy. ABs were the most prevalent causative agents, especially in fatal SRsAs.

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Section: Discussionmentioning

confidence: 99%

Drug-Induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Other amides are safer in this respect, though published data demonstrated their ability to cause anaphylactic shock, that was shown for mepivacaine [38] and bupivacaine [39]. French Pharmacovigilance Database System analysis revealed a twentyfold growth of reports on anaphylactic reactions involving local anesthetics from 1985 to 2020 year, and lidocaine was reported to be the most common cause (81.49%) [40]. Leading role of lidocaine in severe HSRs and in anaphylaxis development in dental practice was stated in the work by Matveev AV et al (2020) [41].…”

Section: Discussionmentioning

confidence: 99%

Drug-induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2023

Preprint

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(1) Background: National health system databases represent one of the most obvious sources of information about epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. (2) Methods: Retrospective analysis of data from national database of pharmacovigilance in the Russian Federation (analyzed period 02.04.2019 - 21.06.2023) was performed. The prevalence of anaphylactic reactions (ARs) was determined, the structure of drugs involved was estimated together with patients’ characteristics. (3) Results: ARs were reported in 8.3% of drug-induced allergic reactions (2304/27,727), mean age of patients was 48.2 ± 15.8 years, 53.2% were females. Main causative groups of drugs were antibiotics, ABs (44.62%), local anesthetics, (19.97%), and cyclooxygenase (COX)-inhibitors (10.07%). Fatal ARs was reported in 9.5% (218/2304), mean age 48.0 ± 16.7 years, 56.2% females. Pediatric population accounted for 5.8% (133/2304), mean age 11.8± 4.5 years, 51.9% females. Elderly population accounted for 2.8% (65/2304), mean age 73.0±5.3 years, 43.5% (27/65) females. ABs were the leading causative groups of ARs in the elderly (40%), children (42.86%), and among fatal cases (50%). (4) Conclusions: ARs accounted for 8.3% of all drug-induced allergic reactions, and ABs were the most common causative agents. Females predominated in all groups except elderly patients.

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“…In 2345 LAs ADR, IgE-mediated anaphylaxis has been found only in 4 cases (0.17%) and without fatal outcome. Lidocaine was the most often involved of LA; mepivacaine, articaine, and procaine were the other LAs listed, but with a much lower frequency [21].…”

Section: Hypersensitivity Reactionsmentioning

confidence: 99%

Local Anesthetic Hypersensitivity Reactions in Pediatric Patients: Recognition and Management

Franceschini,

Bottau,

Caimmi

et al. 2024

Discovery Medicine

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Local anesthetics (LAs) are commonly used in all medical specialties, particularly in association with surgery, obstetrics, dentistry, and emergency departments. Most individuals, starting from young children, are exposed to LAs during life. LA hardly induces adverse events when used in recommended doses and with proper injection techniques. However, immediate anaphylactic reactions to LA injections may be a rare but life-threatening manifestation. A comprehensive report of the event and performing a specialist examination are crucial to prevent further episodes. The diagnosis should be based on history, medical records, skin and challenge tests.

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Anaphylactic reactions to local anesthetics in dental practice: a nationwide French retrospective study

Cited by 8 publications

References 36 publications

Drug-Induced Anaphylaxis: National Database Analysis

Drug-Induced Anaphylaxis: National Database Analysis

Drug-induced Anaphylaxis: National Database Analysis

Local Anesthetic Hypersensitivity Reactions in Pediatric Patients: Recognition and Management

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