Anaphylactic reaction to ampicillin and severe complication in the fetus

Heim, K; Alge, A; Marth, Christian

doi:10.1016/0140-6736(91)92574-l

Cited by 31 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 The potential adverse effects of such widespread antibiotic use are significant. Penicillin anaphylaxis is rare but potentially fatal for mother or infant 22 and less severe allergic reactions are common. Increases in the incidence of neonatal sepsis due to antibiotic resistant bacteria have been reported following widespread use of intrapartum antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and predictive values of risk factors for neonatal group B streptococcal sepsis

Gilbert

Hewitt

Turner

et al. 2002

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

Neither early antenatal screening nor clinical risk factors are reliable predictors of intra-partum GBS carriage. Intra-partum antibiotic prophylaxis based on GBS carriage or risk factors when carrier status is unknown would involve approximately 35% of women, compared with approximately 16% if based on risk factors only Both strategies would prevent similar proportions of neonatal deaths from GBS sepsis. Compliance with a preventive protocol is the most likely determinant of its overall effectiveness.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology and predictive values of risk factors for neonatal group B streptococcal sepsis

Gilbert

Hewitt

Turner

et al. 2002

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

show abstract

“…The higher proportion of potentially preventable cases of sepsis in full-term infants, when GBS carriage late in pregnancy and selected CRF are the criteria for IAP, compared with CRF only 6,11 , must be weighed against the disadvantages of giving antibiotics to nearly twice as many women -as would be indicated in Australia, based on our data 13 . Penicillin anaphylaxis is rare (1-5/10 000) 24 , but can be fatal for mother or infant 25 and less severe allergic reactions are common (5-10%). An increase in the proportion of cases of neonatal sepsis due to penicillin/ ampicillin-resistant bacteria, associated with increased use of IAP, has been reported [26][27][28][29] .…”

Section: Discussionmentioning

confidence: 99%

Compliance With Protocols for Prevention of Neonatal Group B Streptococcal Sepsis: Practicalities and Limitations

Gilbert

Hewitt

Turner

et al. 2003

Infectious Diseases in Obstetrics and Gynecology

View full text Add to dashboard Cite

Objective: To compare two protocols for intrapartum antibiotic prophylaxis (IAP) against neonatal group B streptococcal (GBS) sepsis, with respect to staff compliance, in a prospective cohort study in the obstetric units of a community hospital (A) and a university teaching hospital (B). Methods: Cohorts comprised about 500 women attending antenatal clinics at each hospital (total 1096). Women identified as GBS carriers at 26–32 weeks'gestation and those who had intrapartum clinical risk factors (CRF) were eligible for IAP. Compliance was defined as the proportion of women eligible for IAP who received it according to protocol–as determined by audit of case records–and compared between hospitals and according to indication. Results: Overall, 39% of women were eligible for IAP. Indications were GBS carriage alone (21%), CRF alone (13% ) and both (5% ). Compliance was similar for GBS carriers at both hospitals: 78% at Hospital A and 76% at Hospital B. However, because of the poor predictive value of screening before 32 weeks, only 65%of intrapartum GBS carriers actually received IAP. For women with CRF only, compliance was significantly lower at Hospital B than Hospital A (56 vs. 75%; p= 0.03). Conclusions: According to currently recommended protocols, about one-third of healthy women are eligible for intrapartum antibiotics to prevent neonatal GBS sepsis. In practice, antibiotics are often used inefficiently because of poor compliance with protocols and poor predictive values of selection criteria. Better implementation strategies should improve compliance, but GBS vaccines are needed to replace prophylactic antibiotic use, with its associated disadvantages.

show abstract

“…Anaphylaxis associated with administration of a b-lactam antibiotic as IAP for the prevention of early-onset group B streptococcal infection has been reported, but is rare [171,[646][647][648]. Estimates range from 4 events per 10,000 to 4 per 100,000 patients.…”

Section: Intrapartum Antibiotic Prophylaxismentioning

confidence: 99%