Anaphylactic reaction in the cat following intraventricular and intravenous injections of antigen

IgE responses in cats infected with Brugia pahangi

“…Although it is strongly suspected that cats possess IgE, by the observations of immediate hypersensitivity reactions after mosquito (personal observation) and flea (W.K.Greene personal communication) bites and the induction of passive cutaneous anaphylaxis (PCA) responses in guinea pigs with sera from cats immunized with bovine IgG (Jankovic et al 1969) and cats with sera from a kitten allergic to milk (Parish 1965), there is no Therefore, as specific reagents for cat IgE are not available, sera from cats in all four groups were tested by PCA for the presence of heat sensitive homocytotropic antibody. The principle of this test is that IgE injected intradermally binds firmly for several days to mast cells in the skin.…”

Physiological and haematological findings and clinical observations in a model of acute systemic anaphylaxis inDirofilaria immitis‐sensitised cats

“…12,[17][18][19] This is in marked contrast to the overwhelming pulmonary signs of severe acute dyspnoea reported both in this study and in earlier descriptive reports, seen in feline anaphylaxis. 2,[5][6][7][8] The main physiological effects of D immitis challenge in our experimental model are increased dyspnoea and reduced levels of blood O 2 saturation, expired CO 2 , and systolic blood pressure. Dyspnoea was the most commonly observed clinical change and was present in both challenged groups.…”

“…[1][2][3] There is little published information on the effects of acute systemic anaphylaxis in cats and those reports detail almost entirely subjective assessments and clinical signs rather than objective physiological variables. [2][3][4][5][6][7][8][9] To the authors' knowledge, there are no reports on the haematological effects of acute systemic anaphylaxis in cats.…”

“…2,[10][11][12][13][14] Hypotensive shock is another major cause of death due to anaphylaxis in both species. 5,6,15 There is a relative paucity of in vivo studies of acute systemic anaphylaxis in the scientific literature even though in vivo models are critical to our understanding of the pathogenesis and clinical management of the condition. While in vivo studies document canine anaphylaxis, 14 since the main shock organ in the dog is the hepatic vein, 10,12 the associated physiological mechanisms and clinical signs are completely different to those in humans and cats.…”

Peer Review #2 of "Divergent relationship of circulating CTRP3 levels between obesity and gender: a cross-sectional study (v0.1)"

“…Dysfunctional adipose tissue represents a novel paradigm that mechanistically links obesity to a variety of diseases such as cardiovascular disease. Traditionally adipose tissue is thought of as solely a storage vessel for excess lipids; however, adipose tissue secretes a number of factors, which have essential endocrine roles in regulating biological functions (Garg 2006;Jankovic et al 1969;Wang et al 1986). These adipose tissue-derived secreted factors are collectively called adipokines.…”