Anaphylactic reaction after artificial insemination

Orta, Marta María González; Ordoqui, E.; Aranzábal, A.; Fernández, Cristina; Bartolomé, B; Sánz, M L

doi:10.1016/s1081-1206(10)61831-5

Cited by 21 publications

(13 citation statements)

References 14 publications

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“…If the percentage of positive BAT is only about 50% of skin-test-positive cases [88,89,90], it is also positive in about 40% of the patients with entirely negative skin tests and a positive clinical history of an immediate-type systemic reaction confirmed by provocation [92], who constitute about 25% of all β-lactam-allergic patients. A lower sensitivity has sometimes been found for BAT in whole blood, but this is neither a consistent finding (table 6) nor one obtained by direct comparisons [124]. In studies comparing sensitivity and specificity of BAT with those of sIgE to β-lactam in the same patients [87,88,89, 91, 92], sensitivity of BAT determined by basophil activation was apparently superior (5–10% or more).…”

Section: Clinical Indications Of Batmentioning

confidence: 91%

“…Individual cases of immediate-type allergy to a number of other drugs or materials used in diagnostic or therapeutic procedures have been reported in recent years: iodinated povidone [109], cyclosporine [110], heparin [111, 112], chlorhexidine [113, 114], hydroxyethyl starch [115], patent blue [116, 117], omeprazole [118], hyaluronidase [119], Viscum album [120], Gelofusine [121, 122], dexchlorpheniramine [123] or bovine serum albumin [124]. The main interest of BAT in such cases is to confirm the diagnosis, particularly when skin testing and/or determination of drug-specific IgE are not available.…”

Section: Clinical Indications Of Batmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Weck

Sánz

Gamboa

et al. 2008

Int Arch Allergy Immunol

169

178

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For the diagnosis of allergy, cellular basophil activation tests (BAT), e.g. histamine or sulfidoleukotriene release tests, have long been introduced, but the expression of basophil activation markers such as CD63 and CD203c detected by flow cytometry has attracted more recent attention. A recent opinion paper in this Journal has stressed not only the potential but also the possible pitfalls of flow-cytometric BAT. We have applied clinical validation of various BAT in various ways for several years, and our experience shows that these new technologies have more potentials and perspectives than pitfalls. A comprehensive review of clinically validated studies on allergy to aeroallergens, insect venoms, latex, food allergens and drugs, e.g. myorelaxants, β-lactams, pyrazolones and non-steroidal anti-inflammatory drugs, as well as chronic urticaria shows clearly that even with different protocols, reproducible and meaningful results can be obtained. Although the available technologies may still be optimized and better standardized, there are no serious reasons to deprive allergic patients of clinically indicated BAT, which can be performed reliably by any laboratory with allergy and flow-cytometric capacity and expertise.

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Section: Clinical Indications Of Batmentioning

confidence: 91%

Section: Clinical Indications Of Batmentioning

confidence: 99%

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Weck

Sánz

Gamboa

et al. 2008

Int Arch Allergy Immunol

169

178

View full text Add to dashboard Cite

show abstract

“…Cases involving IAR to corticosteroids [42], heparins [43,44] and omeprazole [45] have demonstrated the usefulness of BAT in evaluating IAR to these drugs. BAT has also been used to evaluate allergy to cyclosporine [46], gelofusine [47], dexchlorpheniramine [48], chlorhexidine [49], iodinated povidone [50] hyaluronidase [51] or BSA [52].…”

Section: Basophil Activation Test In Allergic Reactions To Other Drugsmentioning

confidence: 99%

Basophil activation tests in the evaluation of immediate drug hypersensitivity

Sánz

Gamboa

Mayorga

2009

Current Opinion in Allergy &Amp; Clinical Immunology

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BAT sensitivity in beta-lactam allergy was 50%, and specificity ranged from 89 to 97%. There are several studies to validate the BAT in allergy to muscle relaxants showing a sensitivity ranging from 54 to 64% with a specificity of 100 and 93%. The sensitivity of a test for evaluating immediate allergic reactions to drugs may decrease over time. To date, the BAT is the only in-vitro diagnostic method that has been validated for the diagnosis of both IgE-mediated and hypersensitivity reactions to NSAIDs. With respect to other drugs, they are nonetheless interesting as they include the evaluation of allergy to drugs that cannot be studied by other in-vitro techniques. All these data suggest that although a full validation of the test is required, BAT is a potential diagnostic method for evaluating immediate allergic reactions to drugs and NSAID hypersensitivity reactions.

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“…Recently, BSA has been added to the culture medium of spermatozoids used for artificial insemination. As a result, some case reports have suggested that BSA may be a causative agent in severe anaphylaxis after standard intrauterine insemination or in vitro fertilization [45,46]. These studies reported that the reaction to BSA could be caused by cross-reaction with SAs contained in heterologous allergenic sources.…”

Section: Role Of Mammalian Serum Albumin In Anaphylaxismentioning

confidence: 99%

Role of Sensitization to Mammalian Serum Albumin in Allergic Disease

Liccardi

Asero

D’Amato

et al. 2011

Curr Allergy Asthma Rep

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Serum albumin (SA) constitutes an intriguing puzzle that is involved in allergic sensitizations from different sources and induces different clinical manifestations. In this article, we describe the role of sensitization to SAs in inducing allergic diseases and the complex interactions and cross-reactivity between SA resulting from its presence in various mammalian tissues and fluids. SAs alone are an uncommon cause of allergic sensitization in airways, but these allergenic proteins likely play a significant role as cross-reacting allergens in individuals sensitized to several types of animal dander. SAs are a minor allergen in milk but a major allergen in meats. Recently, bovine SA has been added to the culture medium of spermatozoids used for artificial insemination. As a consequence, some case reports have shown that bovine SA may be a causative agent in severe anaphylaxis after standard intrauterine insemination or in vitro fertilization.

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Anaphylactic reaction after artificial insemination

Cited by 21 publications

References 14 publications

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls

Basophil activation tests in the evaluation of immediate drug hypersensitivity

Role of Sensitization to Mammalian Serum Albumin in Allergic Disease

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