Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c‐fos in the hypothalamus and medulla oblongata

Tanida, Mamoru; Zhang, Tao; Sun, Lixian; Song, Jie; Yang, Wenyan; Kuda, Yuichi; Kurata, Yasutaka; Shibamoto, Toshishige

doi:10.1113/ep086809

Cited by 5 publications

(9 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The afferent vagal signals were conveyed to the NTS in the medulla oblongata. Furthermore, the increased c-Fos expression in the NTS during anaphylaxis (27) was abolished by vagotomy (3). Supporting this finding, we newly found that afferent vagal signals, but not afferent sympathetic signals from the stomach, increased during anaphylactic hypotension.…”

Section: Discussionsupporting

confidence: 72%

“…We (24,25,27) previously reported that efferent sympathetic nerve activity to the kidney, hindlimb, and adrenal glands increased during anaphylactic hypotension in anesthetized rats. Here, we newly found that ef-GSNA increased during anaphylaxis, although the increase was limited to the early phase (1-10 min after antigen injection).…”

Section: Discussionmentioning

confidence: 90%

“…It is well known that efferent autonomic nerves innervating the stomach modulate gastric functions where the excitation of the efferent gastric vagal nerve increases gastric motility (1,6), whereas excitation of the efferent gastric sympathetic nerve increases gastric vascular tone and pylorus contractility (2,18,20). Efferent sympathetic nerve activity to the kidney, adrenal gland, and hindlimb are sensitive to the baroreceptor reflex, as evidenced by sympathoexcitation in response to sodium nitroprusside (SNP)-induced hypotension (24,25,27). However, whether efferent gastric sympathetic nerve activity (ef-GSNA) and efferent gastric vagal nerve activity (ef-GVNA) increase during anaphylactic hypotension or SNP-induced hypotension has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

“…Afferent vagal nerves of the stomach particularly respond not only to chemical stimulation by hormones (5) or neurotransmitters (28) but also to mechanical stimulation by gastric distension (8,17). In addition, afferent vagal nerves of gastrointestinal organs terminate in the medullary nucleus tractus solitarii (NTS) of the brain, and immunohistochemical studies have revealed that anaphylaxis increased c-Fos expression in the NTS (3,27). These lines of evidence suggest that anaphylaxis affects vagal afferents in the stomach.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Kuda

Tanida

et al. 2019

American Journal of Physiology-Regulatory, Integrative and Comp

Self Cite

View full text Add to dashboard Cite

Systemic anaphylaxis is a life-threatening and allergic reaction that affects various organs. We previously reported that, in the stomach, gastric vasoconstriction occurring at the late phase (15–55 min after injection of ovalbumin antigen) was observed in anesthetized rats sensitized with ovalbumin. In addition, anaphylaxis enhances gastric motility and delays emptying. However, the role of extrinsic autonomic nervous system on antigen-induced gastric alterations was not known. Thus, using the same rat anaphylaxis model, we aimed to determine the changes in the efferent and afferent autonomic nerve activities in the stomach during anaphylactic hypotension. The findings showed that injection of ovalbumin antigen caused substantial systemic hypotension in all sensitized rats. The efferent gastric sympathetic nerve activity (ef-GSNA), but not the efferent vagal nerve activity, increased only at the early phase (1–10 min after injection of ovalbumin antigen) and showed baroreceptor reflex, as evidenced by a stimulatory response to sodium nitroprusside-induced hypotension. In general, excitation of ef-GSNA could induce pylorus sphincter contraction and gastric vasoconstriction. In the present study, we found that sympathectomy attenuated the anaphylaxis-induced decrease in gastric flux but not the increase in gastric vascular resistance. Thus, the increase in ef-GSNA may cause anaphylactic pylorus sphincter contraction but not anaphylactic gastric vasoconstriction. On the other hand, the afferent gastric vagal nerve activity, but not the afferent sympathetic nerve activity, increased during the early phase of anaphylactic hypotension. However, vagotomy produced no effects on the anaphylactic gastric dysfunction. In conclusion, the gastric sympathetic nerves partly modulate stomach function during systemic anaphylaxis.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Kuda

Tanida

et al. 2019

American Journal of Physiology-Regulatory, Integrative and Comp

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previously, we have shown that the hypothalamic AMPK also regulates leptin-induced renal sympathoexcitation and blood pressure elevation in rats (6,14). The efferent sympathetic signal to the kidney is a baroreceptor reflex-related nerve that responds to sodium nitroprusside-induced hypotension (20). Gastric SNA (10) and splenic SNA (data not shown) also increased during hypotension after sodium nitroprusside injection.…”

Section: Discussionmentioning

confidence: 69%

Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats

Tanida

Iwasaki

Yamamoto

2019

In Vivo

Self Cite

View full text Add to dashboard Cite

Background/Aim: Leptin, one of the hormones produced in white adipose tissue, is an efferent sympathetic stimulator. Actually, an injection of leptin into the brain has been shown to activate sympathetic nerve activities innervating the kidney, adrenal gland, adipose tissues, liver, and lumbar in rats. Materials and Methods: This study investigated the effects of an intracerebroventricular injection of leptin on the activities of sympathetic nerves innervating the stomach and spleen in anesthetized rats. Results: Leptin injection activated the neural activities of sympathetic traffic to both the stomach and spleen. In addition, to investigate the role of AMP-activated protein kinase (AMPK), the effects of 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an AMPK activator, or compound C, an AMPK inhibitor, on leptin-induced sympathoexcitation, were assessed. Central pretreatment with AICAR or compound C eliminated not only leptin-induced gastric sympathoexcitation but also leptin-induced splenic sympathoexcitation. Conclusion: Leptin stimulates efferent sympathetic outflow to the stomach and spleen through the hypothalamic AMPK. Appetite is regulated by certain hormones, such as leptin, ghrelin, cholecystokinin, and peptide YY, released from peripheral organs (1). These hormones directly act on the hypothalamus or affect the brain by acting on afferent autonomic nerves in gastrointestinal organs (2). Leptin, a 1827 This article is freely accessible online.

show abstract

Mechanisms for hypothermia during anaphylactic hypotension in awake rats

Shibamoto,

Ono,

Tanida

et al. 2023

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Hypothermia develops during systemic anaphylaxis in rodents. The aim of this study to was to elucidate the mechanism for the hypothermia by assessing roles of locomotor activity, tail heat dissipation, heat production in the brown adipose tissue (BAT) activity and chemical mediators during ovalbumin-induced anaphylactic hypotension in awake rats. We measured the core body temperature (Tcore) and mean blood pressure (MBP), along with the surface temperature of the interscapular region (TiScap), an indirect measure of BAT activity, and the tail (Ttail). During anaphylaxis, MBP decreased to the nadir of 53±2 mmHg at 8 min with recovery toward baseline. Tcore began to decrease at 7.5 min with the nadir of 36.1±0.2°C at 30 min from the baseline of 38.0±0.1°C. TiScap also significantly decreased, but its onset was preceded by that of Tcore. Ttail decreased after antigen, suggesting the absence of increased heat dissipation from the tail. The physical activity, as evaluated by moved distances, did not decrease until 20 min after antigen, followed by a progressive decease. Reduced movement using a restraint maneuver not only reduced Tcore in non-sensitized rats, but also augmented the anaphylactic hypothermia in the early phase (1.5-18 min) in sensitized rats. Combined antagonism against platelet-activating factor (PAF) and histamine H1 receptors abolished antigen-induced hypotension, but only attenuated hypothermia. In conclusion, decreased locomotor activity, but not tail heat dissipation or decreased BAT activity, may at least in part contribute to this hypothermia. PAF and histamine are involved mainly in hypotension, but only partly in hypothermia during rat anaphylaxis.

show abstract

Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c‐fos in the hypothalamus and medulla oblongata

Cited by 5 publications

References 42 publications

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats

Mechanisms for hypothermia during anaphylactic hypotension in awake rats

Contact Info

Product

Resources

About