Anaphylactic contraction (Schultz‐Dale reaction) of the bovine bronchial artery in vitro

Abstract

Bronchial arteries from sensitized calves contracted on antigenic challenge in the absence and presence of selected anti-allergic drugs and autonomic agents in vitro. Anaphylactic reactivity was inhibited by tripelennamine, isoprenaline and aminophylline, and potentiated by indomethacin and dopamine. Disodium cromoglycate, compound FPL 55712 and ketanserin failed to inhibit anaphylactic contraction.

Antigen-Induced Contraction of Human Isolated Lung Preparations Passively Sensitized with Monoclonal IgE: Effects of Indomethacin

“…While antigen-induced contractions were demonstrable in passively sensitized human bronchial muscle preparations, a similar stimulation produced little or no contraction in the human isolated passive ly sensitized pulmonary arterial and venous muscle preparations. In contrast, previous reports have shown antigen-induced contractions of hovine isolat ed pulmonary vascular muscle preparations [9,10] as well as several pulmonary vascular tissues from the rabbit [11], horse [12] and cat [13]. The difference be tween these results and the data presented in this re port may be due to the various techniques involved in the sensitization process, since these vascular prep arations were derived from animals which had been actively sensitized.…”

Pharmacological studies of pulmonary anaphylaxisin vitro: A review

“…The reactivity of bovine and ovine bronchial arteries to autacoids and autonomic agents has been described [179,180]. Recently the Schultz-Dale reaction was reported in the calf bronchial artery and shown to be inhibited by tripelennamine, isoproterenol, and aminophylline and potentiated by indomethacin and dopamine [181]. The reaction was not affected by disodium cromoglycate, compound FPL55712 and ketanseri.n.…”