Anaphase B: Long-standing models meet new concepts

Vukušić, Kruno; Tolić, Iva Marija

doi:10.1016/j.semcdb.2021.03.023

Cited by 22 publications

(30 citation statements)

References 143 publications

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“…These two steps may be temporally divided in some organisms while occurring simultaneously in other organisms. These two steps are called anaphase A and anaphase B, respectively [ 55 ]. In human mitotic cells, anaphase B usually starts 30–50 s later than the start of the anaphase A [ 46 , 56 ].…”

Section: Cell Cycle Progression Through Various Phasesmentioning

confidence: 99%

“…In human mitotic cells, anaphase B usually starts 30–50 s later than the start of the anaphase A [ 46 , 56 ]. During anaphase, the spindle elongates 8 µm and additional 3 µm in telophase [ 46 , 55 ].…”

Section: Cell Cycle Progression Through Various Phasesmentioning

confidence: 99%

“…A nuclear membrane forms around each set of chromosomes to divide the nuclear DNA from the cytoplasm. Simultaneously, the chromosome decondensation begins [ 55 ].…”

Section: Cell Cycle Progression Through Various Phasesmentioning

confidence: 99%

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Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Wang

2021

Cells

108

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The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving force of cell cycle progression is growth factor-initiated signaling pathways that control the activity of various Cdk–cyclin complexes. While the mechanism underlying the role of growth factor signaling in G1 phase of cell cycle progression has been largely revealed due to early extensive research, little is known regarding the function and mechanism of growth factor signaling in regulating other phases of the cell cycle, including S, G2, and M phase. In this review, we briefly discuss the process of cell cycle progression through various phases, and we focus on the role of signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases.

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Section: Cell Cycle Progression Through Various Phasesmentioning

confidence: 99%

Section: Cell Cycle Progression Through Various Phasesmentioning

confidence: 99%

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Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Wang

2021

Cells

108

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“…We still do not know exactly what the biological function is of maintaining chromosomes separated from each other in early mitosis. A possible hypothesis could be that if chromosomes cluster prematurely, the spindle could not easily capture the kinetochores thus leading to spindle structural defects or mitotic delay as some studies seem to suggest [ 7 , 22 , 38 , 52 , 53 ]. However, other studies have reported normal proliferation in cells depleted of Ki-67 [ 54 ].…”

Section: Outlook and Future Directionsmentioning

confidence: 99%

“…The progression of cells from metaphase into anaphase is defined by the separation of sister chromatids when the protease separase cleaves the cohesin rings. During the first part of anaphase, the kinetochore microtubules shorten, and the chromosomes move toward the spindle poles (anaphase A) [ 6 ], followed by the spindle poles separation (anaphase B) [ 7 ]. At the end of this mitotic stage, the chromosomes reach their maximum compaction and cluster together ( Figure 1A , panel 4).…”

Section: Introductionmentioning

confidence: 99%

Chromosome clustering in mitosis by the nuclear protein Ki-67

Σταματίου

Vagnarelli

2021

Biochemical Society Transactions

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Ki-67 is highly expressed in proliferating cells, a characteristic that made the protein a very important proliferation marker widely used in the clinic. However, the molecular functions and properties of Ki-67 remained quite obscure for a long time. Only recently important discoveries have shed some light on its function and shown that Ki-67 has a major role in the formation of mitotic chromosome periphery compartment, it is associated with protein phosphatase one (PP1) and regulates chromatin function in interphase and mitosis. In this review, we discuss the role of Ki-67 during cell division. Specifically, we focus on the importance of Ki-67 in chromosome individualisation at mitotic entry (prometaphase) and its contribution to chromosome clustering and nuclear remodelling during mitotic exit.

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Cell Cycle Progression and Synchronization: An Overview

Wang

2022

Methods in Molecular Biology

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Anaphase B: Long-standing models meet new concepts

Cited by 22 publications

References 143 publications

Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Chromosome clustering in mitosis by the nuclear protein Ki-67

Cell Cycle Progression and Synchronization: An Overview

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