Ananas comosus Peels Extract as a New Natural Cosmetic Ingredient: Oil-in-Water (O/W) Topical Nano Cream Stability and Safety Evaluation

Abstract

Ananas comosus peels (AcP) are among the agro-industrial biomasses contributing to a significant volume of waste in Malaysia. Thus, the AcP extract (AcPE) may prove useful for other applications, such as an ingredient in a nanocream for controlled delivery for dermal application. Therefore, this study aimed to develop an oil-in-water (O/W) nanocream using ingredients derived from the AcPE and test its stability alongside safety evaluation. The extract is a rich source of polyphenolic compounds viz., catechin, quercetin, and gallic acid. The study discovered that the optimized AcPE nano cream was stable against coalescence during the accelerated test but was influenced by Ostwald ripening over 6 weeks of storage at 4°C. Safety assessments affirmed the AcPE nano cream to be free of microbial contamination and heavy metals. The findings conveyed that the A. comosus nano cream is a good cosmetic ingredient and may contribute to the cosmeceutical industry’s new and safe topical products.

Nanoemulsion-based plant essential oil formulations: in vitro evaluation of pesticidal activity against ectoparasites in poultry

“…Cosurfactants are often required because their free energy is higher than that of separate oil and water phases ( Cimino et al, 2021 ). Many studies have reported the use of surfactants and cosurfactants as emulsifiers in nanoemulsions of EOs in water, including poloxamer 188, lecithin, PluronicF68, Tween60, Tween80, decanoyl/octanoyl-glycerides, glycerin monostearate, span 8, and polyethylene glycol 400 ( PEG400 ) ( Shi et al, 2016 ; Cimino et al, 2021 ; Doungnapa et al, 2021 ; Singh et al, 2021 ; Yahya et al, 2022 ). In this study, Tween60 and Tween80 were used as surfactants, and PEG400 was used as a cosurfactant in the nanoemulsion-based formulations of different oils and their ratios, following the recommendations of Doungnapa et al (2021) .…”