Analyzing the role of soil and rice cadmium pollution on human renal dysfunction by correlation and path analysis

Luo, Hui-Fang; Zhang, Jieying; Jia, Wenjing; Ji, Fengmin; Yan, Qiliang; Qing, XU; Shi, Ke; Ke, Jinshan

doi:10.1007/s11356-016-7845-0

Cited by 17 publications

(4 citation statements)

References 31 publications

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“…Cd has an extremely long biological half-life. Unlike other complex organic pollutants, Cd cannot be degraded by microorganisms, enters the food chain through contact with Cd in paints, fertilizers, cosmetics, automobiles, and batteries resulting in Cd accumulation in ecosystems 2 . Cd exhibits multi-organ toxicity in the heart, brain, liver, bone, and kidney 3 .…”

Section: Introductionmentioning

confidence: 99%

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture

Liu

Yuan

Long

et al. 2017

Sci Rep

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The Fas/FasL signaling pathway is one of the primary apoptosis pathways, but the involvement and regulatory mechanism of this pathway by autophagy remain unclear. Here we demonstrated that cadmium (Cd) activated the Fas/FasL apoptosis pathway in rat proximal tubular (rPT) cells; this was accompanied by simultaneous activation of autophagy resulted in reduced apoptosis. In this model, we induced autophagy through RAPA and further demonstrated that autophagy protects against activation of Fas/FasL signaling and apoptosis. The antiapoptotic effect of autophagy was blocked by 3-MA, an autophagy inhibitor. The interactions between Beclin-1 and Fas, FasL, FADD, caspase-8 and BID/tBID were relatively weak, with the exception of cleaved caspase-8, indicated that minimal interactions between these proteins and Beclin-1 are involved in maintaining the balance of autophagy and apoptosis. Beclin-1 precipitated with cleaved caspase-8 in a dose-dependent mannter, and the expression was increased by siRNA against Beclin-1. These data suggested that Beclin-1-mediated autophagy impairs the expression and function of cleaved caspase-8 to protect against Cd-induced activation of apopotosis through Fas/FasL signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture

Liu

Yuan

Long

et al. 2017

Sci Rep

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“…Codo et al (2016) in Sweden reported that the men and women with the CKD differed with regard to underlying pathophysiology of the disease and its complications, presented with different signs and symptoms, with different responds to therapy and tolerate/cope with the disease differences. Luo et al (2017) in China investigated the role of soil and rice pollution on human renal dysfunction. They found that the effects of S-Cd on renal health even as significant as R-Cd to protect people from the cadmium pollution damage, which was vital to monitor the situation of soil and rice cadmium pollution.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Parasites and Microsporidia in Patients With Chronic Kidney Disease, Sohag Governometal Hospitals

EL-MAWGOOD¹,

EL-NAZER²,

MOHAMED³

et al. 2022

Journal of the Egyptian Society of Parasitology

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Parasitosis causes significant morbidity and mortality among immunosuppressed hosts. Acquisition of infection, clinical severity, and outcome of a parasitic disease depend on innate and acquired host immunity andThis study evaluated parasitic infections among patients with chronic kidney disease (CKD) from Sohag Governorate Hospitals. A total of 100 morning stool samples were collected from the patients and another 100 stool samples from healthy control from January to May 2020. Each sample was divided into two parts; one part for microscopic examination, and the second was preservation and late need. The intestinal parasites were 66/100 CKD patients (66%), whom 25 with nephritic syndrome and 41 on dialysis patients compared to 31/100 controls. The results showed that the commonest one was Cryptosporidium pyrvum with or without Microsporidia spores.

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“…The correlation coefficient was decomposed into direct effects and indirect effects by path analysis, with the result that the relative importance of the temperature and solar radiation for the lodging resistance were revealed. The values of direct and indirect effects were calculated according to the study of Luo et al [77]. The GraphPad Prism software for Windows (Ver.…”

Section: Discussionmentioning

confidence: 99%

Responses of the Lodging Resistance of Indica Rice Cultivars to Temperature and Solar Radiation under Field Conditions

Luo

et al. 2022

Agronomy

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Much attention has shifted to the effects of temperature and solar radiation on rice production and grain quality due to global climate change. Meanwhile, lodging is a major cause of rice yield and quality losses. However, responses of the lodging resistance of rice to temperature and solar radiation are still unclear. To decipher the mechanisms through which the lodging resistance might be affected by temperature and solar radiation, 32 rice cultivars with different lodging resistance were grown at two eco-sites on three sowing dates over a period of three years. Based on the field observation, 12 indica rice cultivars which did not lodge were selected for analysis. Significant differences were found in the lodging resistance of the indica rice cultivars at different temperature and solar radiation treatments. The results showed that temperature was the main factor that affected the lodging resistance of indica rice cultivars under the conditions of this study. With the increased average daily temperature, the lodging resistance decreased rapidly, primarily due to the significant reduction in physical strength of the culm, which was attributed to the longer and thinner basal second internode. Among the 12 indica rice cultivars, the lodging-moderate cultivar Chuanxiang 29B was most sensitive to temperature, and the lodging-resistant cultivar Jiangan was least responsive to temperature. These results suggested that rice breeders could set the shorter and thicker basal internode as the main selection criteria to cultivate lodging-resistant indica cultivars to ensure a high yield at a higher ambient temperature.

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Analyzing the role of soil and rice cadmium pollution on human renal dysfunction by correlation and path analysis

Cited by 17 publications

References 31 publications

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture

Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture

Intestinal Parasites and Microsporidia in Patients With Chronic Kidney Disease, Sohag Governometal Hospitals

Responses of the Lodging Resistance of Indica Rice Cultivars to Temperature and Solar Radiation under Field Conditions

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