Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells

Abstract

This research aims at analyzing the effect of microRNAs on hepatogenic Differentiation of mesenchymal stem cells. According to the results, miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p were definitely overexpressed during hepatic differentiation of hMSCs. Also the results indicate that ectopic overexpression of miR-122 cannot initiate hepatic differentiation of hMSCs. In other words, hMSCs can be converted into functional hepatocytes only if all the miRs (miR-122, miR-1246, miR-1290, miR-148a, miR-30a, miR-424, and miR-542-5p) are used.