Analyzing the Association between Candida Prevalence, Species Specificity, and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis— Candida and OSCC

Patil, Shankargouda

doi:10.3390/app10031099

Cited by 7 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study showed Candida albicans to be the most common species found among cancer patients, followed by that Candida tropicalis which was similar to that of the studies carried out by Schelenz and Safdar et al [38,39]. The most common non-Candida species among cancer patients was Candida glabrata, as reported in some studies [40][41][42][43][44]. This is also in agreement with the findings of Abidullah et al, who reported the presence of C. glabrata in patients with oral squamous cell carcinoma [40].…”

Section: Discussionsupporting

confidence: 87%

Evaluation of Candidiasis in Upper-Aerodigestive Squamous Cell Carcinoma Patients—A Clinico-Mycological Aspect

Debta

Swain

Sahu

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

Candida is a commensal yeast. It can be infective when the host’s defense mechanism is weakened, as in the case of squamous cell carcinoma patients. We aimed to evaluate the prevalence and clinical mycological manifestation of candidiasis in 150 cancer cases comprised of preoperative and post-operative (with or without radiotherapy) upper aerodigestive squamous cell carcinoma. A total of 150 patients suffering from squamous cell carcinoma of the Upper Aero-Digestive Tract (UADT) were divided into preoperative (n = 48), post-operative without radiotherapy (n = 29) and post-operative with radiotherapy (n = 73). Samples were collected using cotton swabs and cultured. Candida species were identified according to color pigmentation on Candida Differential Agar (CDA) plate. The clinico-mycological association of patients was evaluated by the chi-square test, and 98 out of 150 patients showed the presence of various Candida species. The major species isolated was Candida albicans (53%), followed by Candida tropicalis (16%). There was a significant statistical difference between patients who showed mycological associations and patients who did not have any such association (p = 0.0008). The prevalence of oral candidiasis was found to be 65.33% among total cases of upper aero-digestive squamous cell carcinoma. Chronic erythematous cases of candidiasis were mainly seen in preoperative squamous cell carcinoma cases, whereas the acute erythematous type of candidiasis was mainly seen in post-operative cases who received radiotherapy. The clinicomycological assessment can help to correlate the signs and symptoms with the presence of candidiasis in upper aerodigestive squamous cell carcinoma patients. Meticulous testing and examination can help in the early detection of candidiasis. Future studies are needed to develop advance scientific preventive strategies for high-risk cases.

show abstract

Section: Discussionsupporting

confidence: 87%

Evaluation of Candidiasis in Upper-Aerodigestive Squamous Cell Carcinoma Patients—A Clinico-Mycological Aspect

Debta

Swain

Sahu

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…OSCC are most often preceded by clinically apparent oral potentially malignant disorders (OPMD).The presence of Candida species in oral leukoplakia has strengthened its association to with OSCC as well [3]. Candida species have been linked to etiopathogenesis of OSCC and oral potentially malignant disorders considering its potential to nitrosylate N-benzyl methylamine [4,5].…”

Section: Introductionmentioning

confidence: 99%

A comparative study of Candida species diversity among patients with oral squamous cell carcinoma and oral potentially malignant disorders

2020

View full text Add to dashboard Cite

Objectives To determine the prevalence of Candida species by PCR–RFLP method in the saliva of patients with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD) and healthy cohorts. Unstimulated saliva was collected from patients with OSCC (n = 97), OPMD (n = 200), and healthy controls (n = 200). Candida species were isolated using the standard protocol. The isolates were identified using phenotypic and genotypic methods. The odds/risk ratio was calculated using Pearson’s Chi-square test. The significance of Candidal carriage was calculated by independent T-test. Results Oral Candidal carriage was 72.2%, 58% and 20.5% among patients with OSCC, OPMD, and healthy controls respectively. The oral Candidal carriage in OSCC and OPMD was highly significant (p = 0.0001). Non albicans Candida predominated over Candida albicans. Candida species were diverse among the study groups with a predominance of Candida krusei, Candida tropicalis, and Pichia anomala formerly Candida pelliculosa. P. anomala occurrence outnumbered in health. The odds/risk ratio for OSCC and OPMD were 4.25/11.87 and 3.52/6.99 respectively. A high prevalence of non albicans Candida was observed both in all the three groups (OSCC, OPMD and healthy controls). High odds and risk ratio associates Candida species to OSCC and OPMD. Candida famata may be associated with OSCC and OPMD.

show abstract

“…Additionally, it has been shown that C . albicans produces carcinogens such nitrosamines, which have the ability to activate proto-oncogenes and cause carcinomatous alterations ( 105 ). A C .…”

Section: Oral Bacteria Associated With Osccmentioning

confidence: 99%

“…This adhesion can weaken the host's defense mechanisms, allowing for further infection (104). Additionally, it has been shown that C. albicans produces carcinogens such nitrosamines, which have the ability to activate proto-oncogenes and cause carcinomatous alterations (105). A C. albicans infection-related chronic inflammation may also play a role in the development of cancer.…”

Section: Candidamentioning

confidence: 99%

Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms

Sukmana,

Saleh,

Najim

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic bacteria, in particular Porphyromonas gingivalis and Fusobacterium nucleatum, have been closely linked to OSCC. Moreover, certain oral fungi, such as Candida albicans, and viruses, like the human papillomavirus, have also been implicated in OSCC. Despite these findings, the precise mechanisms through which the oral microbiota influences OSCC development remain unclear and necessitate further research. This paper provides a comprehensive overview of the oral microbiota and its relationship with OSCC and discusses potential carcinogenic pathways that the oral microbiota may activate or modulate are also discussed.

show abstract

Analyzing the Association between Candida Prevalence, Species Specificity, and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis— Candida and OSCC

Cited by 7 publications

References 59 publications

Evaluation of Candidiasis in Upper-Aerodigestive Squamous Cell Carcinoma Patients—A Clinico-Mycological Aspect

Evaluation of Candidiasis in Upper-Aerodigestive Squamous Cell Carcinoma Patients—A Clinico-Mycological Aspect

A comparative study of Candida species diversity among patients with oral squamous cell carcinoma and oral potentially malignant disorders

Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms

Contact Info

Product

Resources

About