“…The accurate identification of CAD and non-CAD instances may be impacted by the unbalanced distribution of the instances in the two classes. Here, an oversampling method is applied, namely SMOTE [ 49 ], which is based on the K-Nearest Neighbors (KNN) [ 50 ] classifier with and creates synthetic data [ 51 ] on the minority class (see Algorithm 1). The instances in the CAD class are oversampled, such that the subjects in the two classes are uniformly distributed.…”