“…Moreover, SOD1 has been shown to be glycated in vivo and glycation sites have been identified and they are six lysine residues (number 3, 9, 30, 36, 122, 128) spread along the protein sequence [ 152 ]. SOD1 glycation has been studied in vitro in the presence of different glycating agents and the effects of glycation in amyloid aggregation has been also evaluated [ 153 , 154 , 155 ]. In particular, SOD1 can be efficiently glycated in vitro by glucose, D-ribose, GO, and MGO and glycation was shown to promote protein unfolding, loss of copper binding and inhibition of the enzymatic activity [ 154 , 156 , 157 , 158 ].…”