Analyzing of L-tryptophan thermodynamics and its solubility in aqueous acetonitrile blends at diverse temperatures

Saha, Avishek; Ghosh, Sourav; Ganai, Sintu; Mukherjee, Puspal; Mahali, Kalachand; Saha, Bidyut; Henaish, A.M.A.; Guin, Partha Sarathi; Alam, Perwez; Roy, Sanjay

doi:10.1016/j.bpc.2024.107195

Cited by 1 publication

(2 citation statements)

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“…The measurement of APZ solubility was divided into two methods due to the fact that in preliminary experiments, it was found that APZ transformed relatively quickly into other solid forms in certain solvents. The solubilities of APZ in seven solvents (AC, ACN, EA, IPA, NBA, NOT, and NPA) were measured using gravimetric methods because APZ does not undergo a solid-phase transformation in these seven solvents or transforms very slowly. − First, excess amount of APZ solid powder was added into a 100 mL glass-jacketed crystallizer (Tianjin Yipujia Technology Co., Ltd., China) containing about 50 mL of solvents. A glass mercury thermometer with an uncertainty of ±0.05 K was inserted into the crystallizer to measure the solution temperature.…”

Section: Methodsmentioning

confidence: 99%

“…Currently, solubility measurement methods and correlation methods are well established. The gravimetric and dynamic methods are the two most commonly used methods for measuring solubility. − The gravimetric method is suitable for measuring the solubility of stable systems, while the dynamic method is suitable for measuring the solubility of systems that are prone to phase transformations. After the solubility is obtained, the solubility data can usually be correlated to obtain some thermodynamic properties of the dissolution process (e.g., dissolution enthalpy, dissolution entropy, dissolution Gibbs free energy, etc.)…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Intermolecular Interactions on the Dissolution Property of Aripiprazole

Zheng,

Huang,

Gao

et al. 2024

Crystal Growth & Design

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The measurement and prediction of solubilities of active pharmaceutical ingredients are crucial in the development of polymorphism and the crystallization process. In this work, the solubilities of aripiprazole (APZ) in 11 pure solvents were measured and correlated over the temperature range 293.15−333.15 K. It was found that in all studied solvents, the solubility of APZ increased with the increasing temperature throughout the entire investigated temperature range. In addition, the mixing and dissolution thermodynamic properties of APZ in 11 pure solvents were also calculated. The calculation results indicated that both the mixing and the dissolution processes of APZ are spontaneous. Moreover, the intermolecular interactions in APZ solutions were investigated by molecular surface electrostatic potential analysis, independent gradient model based on Hirshfeld partition analysis, and molecular dynamics simulations. The results showed that the van der Waals interactions had a significantly greater effect on the dissolution process of APZ than did the hydrogen bond interactions. The solubility of APZ was controlled by a combination of the relative magnitude of the newly formed solute−solvent intermolecular interactions and the solvent−solvent intermolecular interactions that were disrupted due to the addition of solute. Finally, a physical quantity, dissolution-driven energy (E dis-driven ), was proposed to predict the APZ dissolution tendency in different pure solvents, which was able to characterize the solubility orders of APZ in different pure solvents almost perfectly.

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