Analyzing Mycobacterium tuberculosis proteomes for candidate vaccine epitopes

McMurry, Julie A.; Sbai, Hakima; Gennaro, Maria Laura; Carter, E.J.; Martin, William; Groot, Anne S. De

doi:10.1016/j.tube.2004.09.005

Cited by 77 publications

(45 citation statements)

References 47 publications

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“…New approaches to identifying genes from completed M. leprae genome sequences are being applied using standardized bioinformatics tools (253). These tools can identify proteins with special features, such as unique or shared amino acid sequence homologies with proteins of M. tuberculosis or other mycobacterial species, and the presence of specialized peptide signatures suggesting their cellular location and possible secretion across the cell membrane.…”

Section: Prevention: the Quest For A Leprosy Vaccinementioning

confidence: 99%

The Continuing Challenges of Leprosy

et al. 2006

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SUMMARY Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases.

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Section: Prevention: the Quest For A Leprosy Vaccinementioning

confidence: 99%

The Continuing Challenges of Leprosy

et al. 2006

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“…One of the unique features of this algorithm is that allele-specific scores are normalized, making it possible to compare scores of any 9-mer across multiple HLA alleles and enabling a more broad assessment of predicted immunogenicity [36]. The predictive value of this algorithm has been extensively tested and is supported by published in vitro and in vivo studies [40, [45][46][47][48][49][50].…”

Section: In Silico Analysis Toolsmentioning

confidence: 99%

Immunogenicity of Therapeutic Fusion Proteins: Contributory Factors and Clinical Experience

Jawa

Cousens

Groot

2013

Fusion Protein Technologies for Biopharmaceuticals

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“…The protective response was superior to that of the mature protein without the SP and was highly specific, as frameshift mutation in the Ag2/PRA SP sequence abolishes the specific activity (27). McMurry et al identified an M. tuberculosis-originated, SP-derived sequence that induced IFN-␥ secretion in a large percentage of PBMC taken from M. tuberculosis-immune subjects (31).…”

Section: Discussionmentioning

confidence: 99%