Analyzing hematological indices and clinical associations of FLT3 mutation in acute leukemia

Abstract

Objective: The purpose of this research is to examine the relationship between FLT3 mutation and hematological indices and clinical correlates in patients with severe myelogenous leukemia & acute lymphoblastic leukemia. Study Design: Descriptive Study. Place and Duration: Diagnostic and research Laboratory Liaquat university of Medical and health sciences jamshoro Hyderabad. January 2021 to December 2021. Methods: Total 79 cases of acute leukemia were included in this study. Patients provided written consent for detailed demographics and for self-structure questionnaire. All the data was obtained from laboratory records. The patients' clinico-hematologic and immunophenotypic characteristics were recorded, and the FLT3 mutation was analyzed molecularly. SPSS 24.0 was used to analyze all data. Results: Majority of the patients 44 (55.7%) were males and 35 (44.3%) cases were females. The included patients had mean age 37.21±14.59 years and had mean BMI 23.6±4.18 kg/m2. We found that 48 (60.8%) cases had acute myeloid leukemia (AML) and 31 (39.2%) cases had acute lymphoblastic leukemia (ALL). Frequency of FLT 3 mutations in AML patients was 6 (12.5%) and in ALL patients was 1 (3.2%) after polymerase chain reaction. WBC was the most statistically significant hematological and clinical result connected with FLT3 mutation.