Analyzing hedyotis diffusa mechanisms of action from the genomics perspective

Investigating the Multi-Target Pharmacological Mechanism of Hedyotis diffusa Willd Acting on Prostate Cancer: A Network Pharmacology Approach

“…This result indicated that HDW had the potential to affect a diverse range of cancers, such as prostate cancer, bladder cancer, colorectal cancer, and small cell lung cancer, which was confirmed by other researchers [18,26]. This KEGG enrichment result showed that HDW was highly involved in the regulation of angiogenesis, cell differentiation, migration, apoptosis, invasion, and proliferation [20,23]. Therefore, we speculate that the underlying mechanism of HDW against PCa may be due to its coordinated regulation of several cancer-related pathways [26].…”

“…According to the literature, it has been used as a major component in several Chinese medicine formulas to treat cancer, as well as to provide a benefit against the adverse reactions of chemotherapy [19,20]. Moreover, its usage as an anti-tumor herb to treat different types of cancer, including prostate cancer, gastric cancer, colorectal cancer, liver cancer, breast cancer, and ovarian cancer, has been approved by research [21,22,23,24]. According to current pharmacology research, some ingredients with anti-cancer activities, such as anthraquinones, polysaccharides, flavones, hemiterpenes, polyphenols, and organic acids are contained in HDW [19,22,25].…”

“…According to current pharmacology research, some ingredients with anti-cancer activities, such as anthraquinones, polysaccharides, flavones, hemiterpenes, polyphenols, and organic acids are contained in HDW [19,22,25]. It was also reported to possess a variety of bioactivities, such as anti-cancerous, anti-oxidant, anti-inflammatory, and hepatic-protective activities [17,23,24]. However, although many cancer studies confirmed that HDW exhibited noticeable anti-tumor effects, the potential mechanisms of its anti-tumor effects have not yet been fully explored [26,27].…”

Novel Antiviral Efficacy of Hedyotis diffusa and Artemisia capillaris Extracts against Dengue Virus, Japanese Encephalitis Virus, and Zika Virus Infection and Immunoregulatory Cytokine Signatures

“…TCM describes HD and AC as herbs that possess capabilities in clearing away the “evil heat” (i.e., fevers, including those that are a result of infection). Additionally, TCM views HD and AC herbs as approaches in “dispelling evil”, which may correspond to either pathogen inhibition, immune regulation, inflammation control, or host tissue protection [ 44 , 45 , 46 ]. As TCM does not identify the specific therapeutic target and mechanisms in the context of contemporary biological theories, there are limited data on the efficacy and mechanisms of HD and AC against virus infections.…”