Analyzing genetic polymorphism and mutation of 44 Y-STRs in a Chinese Han population of Southern China

Lin, Hanguang; Ye, Qiansu; Tang, Peizhi; Tian, Min; Yu, Xin; Tang, Jianpin

doi:10.1016/j.legalmed.2019.101643

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…The probabilities of observing at least one mutation with the eight RM Y‐STR set and 13 RM Y‐STR set in 1015 DNA‐confirmed father‐son pairs (only including one father‐one son pairs in CSEH) were 0.1852 (95% CI, 0.1618 to 0.2105) and 0.2099 (95% CI, 0.1852 to 0.2362). The ability (distinguishing 18.52–20.99% CSEH father–son pairs) was much lower than the 13 RM Y‐STR set in Europe (70% of father–son pairs) because of the limited Y‐STR markers and different mutation rates in different populations [14,23,43–60], which indicated that the 13 RM Y‐STR set was not always suitable for every population, and new RM Y‐STRs needed to be found and evaluated for different populations.…”

Section: Resultsmentioning

confidence: 99%

“…3C) where bordered the East China Sea, Taiwan Strait, and the South China Sea. In order to assess the degrees of differentiation of CSEH, we collected 50 778 individuals from 166 worldwide populations who belong to nine main language families [21,24,30–32,61–116]. Based on the frequencies of 27 Y‐filer Plus markers, we made a Manhattan distance‐based MDS that indicated that CSEH clustered with populations of southern China in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…From the comparisons of Y‐STR mutation rates in different populations [14,23,43–60], the mutation rate of DYF399S1a/b was 21.19 × 10 –3 in CSEH compared with 77.3 × 10 –3 for Europeans, 70.1 × 10 –3 for Pakistanis, 62.9 × 10 –3 for Hebei Han, 60.0 × 10 –3 for south and east Turks, 45.9 × 10 –3 for Beijing Han, 40.6 × 10 –3 for Guangxi Han, and 38.5 × 10 –3 for Sichuan Yi, which was ∼1–4 folds greater than CSEH. The same issues occurred at other Y‐STRs, for example, DYS518 and DYF387S1.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Y‐STR landscape of coastal southeastern Han: Forensic characteristics, haplotype analyses, mutation rates, and population genetics

Fan

Zeng

et al. 2021

Electrophoresis

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The Y‐STR landscape of Coastal Southeastern Han (CSEH) living in Chinese southeast areas (including Guangdong, Fujian, and Zhejiang provinces) is still unclear. We investigated 62 Y‐STR markers in a reasonably large number of 1021 unrelated males and 1027 DNA‐confirmed father‐son pairs to broaden the genetic backgrounds of CSEH. In total, 85 null alleles, 121 off‐ladder alleles, and 95 copy number variants were observed, and 1012 distinct haplotypes were determined with the overall HD and DC values of 0.999974 and 0.9912. We observed 369 mutations in 76 099 meiotic transfers, and the average estimated Y‐STR mutation rate was 4.85 × 10–3 (95% CI, 4.4 × 10–3–5.4 × 10–3). The Spearman correlation analyses indicated that GD values (R2 = 0.6548) and average allele sizes (R2 = 0.5989) have positive correlations with Y‐STR mutation rates. Our RM Y‐STR set including 8 candidate RM Y‐STRs, of which DYS534, DYS630, and DYS713 are new candidates in CSEH, distinguished 18.52% of father–son pairs. This study also clarified the population structures of CSEH which isolated in population‐mixed South China relatively. The strategy, SM Y‐STRs for familial searching and RM Y‐STRs for individual identification regionally, could be applicable based on enough knowledge of the Y‐STR mutability of different populations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Y‐STR landscape of coastal southeastern Han: Forensic characteristics, haplotype analyses, mutation rates, and population genetics

Fan

Zeng

et al. 2021

Electrophoresis

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“…Inter-population genetic differences in mutation rates. To assess the differences in the mutation rates of the 14 RM Y-STR between different populations, we combined the obtained data with all previously published data on Chinese 13,15,[23][24][25][26] and European populations 9,18,19,27 (Table 2, Supplementary Table S5, Supplementary Figure S1). For the combined Chinese population, the number of meioses per locus ranged from 3605 (DYS526b) to 4771 (DYS627, DYS570, DYS518, DYF387S1, DYS449 and DYS576).…”

Section: Resultsmentioning

confidence: 99%

Mutation analysis for newly suggested 30 Y-STR loci with high mutation rates in Chinese father-son pairs

Wang

Song

Wang

et al. 2022

Sci Rep

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Rapidly mutating Y-STRs (RM Y-STRs) harbor great potential to distinguish male relatives and achieve male identification. However, forensic applications were greatly limited by the small number of the initially identified 14 RM Y-STRs. Recently, with the emergence of 12 novel RM Y-STRs, an integrated panel named RMplex was introduced, which contains all 26 RM Y-STRs and four fast mutating Y-STRs (FM Y-STRs). To obtain the first data on the mutation rates and father-son differentiation rates of the 30 newly proposed Y-STRs in Chinese populations, we performed an empirical mutation study on 307 DNA-confirmed Chinese paternal pairs. Previously reported mutation rates for 14 RM Y-STRs in Chinese and European populations were pooled and merged with our data. The highest meiosis number for the two groups reached 4771 and 2687, respectively. Five loci showed significant differences between the populations (DYS570, DYS399S1, DYS547, DYS612, and DYF403S1b). For the new panel covering 30 Y-STR loci, our results show extensive differences in the mutation rates between the two populations, as well. 10 RM Y-STR loci showed relatively low mutation rates (10–3–10–2 per meiosis) and 2 FM Y-STR loci had rapid mutation rates (> 10–2 per meiosis) in the Chinese population. Several-fold differences in mutation rates were found in nine Y-STR loci between the Chinese and reference populations, with two loci having significantly higher mutation rates and one locus with a significantly lower mutation rate in the Chinese population (P < 0.05). Eighteen RM Y-STRs (> 10–2 per meiosis), 8 FM Y-STR loci (5×10–3-10–2 per meiosis), 3 moderately mutating Y-STRs (MM Y-STRs, 10–3-5×10–3 per meiosis), and one locus with no observed mutation events were identified in the Chinese population. 40.06% of the Chinese paternity pairs were discriminated with RMplex while only 20.84% with the initial 14 RM Y-STRs, indicating that RMplex is beneficial for distinguishing paternally related males. Future studies on populations of different genetic backgrounds are necessary to obtain comprehensive estimates of mutation rates at these new loci.

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“…CRITIC method. CRITIC (Criteria Importation Through Interrogation Correlation) method [8] is an objective weight assignment method. Compared with objective weighting methods such as standard deviation method and entropy weight method, Critic method can complete the assignment of elements more comprehensively and accurately.…”

Section: Instruction 10mentioning

confidence: 99%

Application of Uncertainty Analysis in Evaluation of Marine Engine Simulator

Shen

Cao

Liang

2022

J. Phys.: Conf. Ser.

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Aiming at the problem of fuzziness and randomness in the evaluation process of marine engine simulator, a comprehensive evaluation model based on subjective and objective combination weighting method and cloud model method is established on the basis of single subjective and objective combination weighting method. Firstly, the combined weighting method is used to determine the comprehensive weight; Then, the standard cloud model is generated by using the cloud model method, and the digital characteristics of the evaluation cloud are obtained through the sample data and cloud computing rules. The digital characteristics of the evaluation cloud are obtained by the backward cloud generator and comprehensive weight; Finally, the similarity between the generated evaluation cloud and the standard cloud model is calculated, so as to evaluate the operation of the student marine engine simulator. The example analysis shows that the evaluation method can scientifically and reasonably evaluate the crew’s operation ability, and is feasible and effective.

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Analyzing genetic polymorphism and mutation of 44 Y-STRs in a Chinese Han population of Southern China

Cited by 15 publications

References 18 publications

The Y‐STR landscape of coastal southeastern Han: Forensic characteristics, haplotype analyses, mutation rates, and population genetics

The Y‐STR landscape of coastal southeastern Han: Forensic characteristics, haplotype analyses, mutation rates, and population genetics

Mutation analysis for newly suggested 30 Y-STR loci with high mutation rates in Chinese father-son pairs

Application of Uncertainty Analysis in Evaluation of Marine Engine Simulator

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