2024
DOI: 10.1101/2024.05.27.595942
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Analyzing functional heterogeneity of effector cells for enhanced adoptive cell therapy applications

Anne-Christine Kiel Rasmussen,
Thomas Morgan Hulen,
David Leander Petersen
et al.

Abstract: Cellular effector function assays traditionally rely on bulk cell populations that mask complex heterogeneity and rare subpopulations. The Xdrop® droplet technology facilitates high-throughput compartmentalization of viable single cells or single-cell pairs in double-emulsion droplets, enabling the study of single cells or cell-cell interactions at an individual level. Effector cell molecule secretion and target cell killing can be evaluated independently or in combination. Compatibility with a wide range of c… Show more

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