Analytical validation of a novel point‐of‐care immunoassay for canine N‐terminal pro‐brain natriuretic peptide analysis

Harr, Kendal E.; Gordon, Sonya G.; Baumwart, Ryan; Feldgreber, Ross; Spiro, Matthew R

doi:10.1111/vcp.13101

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Cardiac troponin I (cTnI) analysis was performed by shipping serum sample aliquots to Texas A&M University (TAMU GI Lab, College Station, TX), which uses a high-sensitivity ADVIA Centaur cTnI assay from Siemens Healthineers (Siemens Medical Solutions USA, Inc., Malvern, PA) that has been validated for use in dogs [ 19 ]. NT-proBNP analysis was performed using the Bionote in-clinic, fluorescence immunoassay diagnostic analyzer Vcheck V200 and a canine NT-proBNP assay (Bionote USA, Big Lake, MN), which has also been validated for clinical use [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year

Linde,

Lahiff,

Krantz

et al. 2024

PLoS ONE

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Domestic dogs can maintain health on complete and well-balanced canine plant-based nutrition (K9PBN). Novel insight on health outcomes in dogs consuming K9PBN is of relevance to veterinary professionals and consumers given a growing interest in non-traditional dog foods with perceived health benefits, while considering potential safety concerns. We aimed to investigate nutritional equivalence by measuring clinical health outcomes in adult dogs fed K9PBN over twelve months compared to a meat-based diet at baseline. We enrolled fifteen clinically healthy adult dogs living in households in Los Angeles County, California in a prospective cohort study and evaluated clinical, hematological, and nutritional parameters in dogs at 0, 6, and 12 months, including complete blood count (CBC), blood chemistry, cardiac biomarkers, plasma amino acids, and serum vitamin concentrations. The study found that clinically healthy, client-owned, adult dogs maintain health, based on physical exams, complete blood count, serum chemistry, plasma amino acids, serum vitamins, and cardiac biomarkers combined with client-reported observations, when fed commercial K9PBN over a twelve-month period. This study is the most comprehensive and longest known K9PBN investigation to date and provides clinically relevant evidence-based nutrition data and new knowledge on outcomes in clinically healthy dogs who thrive without consumption of animal-derived ingredients. These results also provide a valuable foundation for the future study of K9PBN as a potential nutritional intervention for clinically relevant pathologies in canine medicine. Lastly, it is of major relevance to One Health paradigms since ingredients produced independent of industrial food animal production are both more sustainable and help to circumvent ethical dilemmas for maintenance of health in domestic dogs.

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Section: Methodsmentioning

confidence: 99%

Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year

Linde,

Lahiff,

Krantz

et al. 2024

PLoS ONE

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show abstract

“…Cardiac troponin I (cTnI) analysis was performed by shipping serum sample aliquots to Texas A&M University (TAMU GI Lab, College Station, TX), which uses a high-sensitivity ADVIA Centaur cTnI assay from Siemens Healthineers (Siemens Medical Solutions USA, Inc., Malvern, PA) that has been validated for use in dogs 17 . NT-proBNP analysis was performed using the Bionote in-clinic, fluorescence immunoassay diagnostic analyzer Vcheck V200 and a canine NT-proBNP assay (Bionote USA, Big Lake, MN), which has also been validated for clinical use 18 .…”

Section: Methodsmentioning

confidence: 99%

Domestic dogs maintain positive clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year

Linde

Lahiff

Krantz

et al. 2023

Preprint

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Objective: Domestic dogs can maintain health on complete and well-balanced canine plant-based nutrition (K9PBN). Novel insight on health outcomes in dogs consuming K9PBN is of relevance to veterinary professionals and consumers given a growing interest in non-traditional dog foods with perceived health benefits, while considering potential safety concerns. We aimed to investigate nutritional equivalence by measuring clinical health outcomes in adult dogs fed K9PBN over twelve months compared to a meat-based diet at baseline. Animals: Fifteen clinically healthy adult dogs living in households in Los Angeles County, California. Procedures: Prospective cohort study evaluating clinical, hematological, and nutritional parameters in dogs at 0, 6, and 12 months, including complete blood count (CBC), blood chemistry, cardiac biomarkers, plasma amino acids, and serum vitamin concentrations. Results: Clinically healthy, client-owned, adult dogs maintain health, based on physical exams, CBC, serum chemistry, plasma amino acids, serum vitamins, and cardiac biomarkers combined with client-reported observations, when fed commercial K9PBN over a twelve-month period. Clinical Relevance: This study is the most comprehensive and longest known K9PBN investigation to date. It provides clinically important evidence-based nutrition data and new knowledge on outcomes in clinically healthy dogs who maintain health without consumption of animal-derived ingredients. Also, it is of major relevance to One Health paradigms since ingredients produced independent of industrial food animal production are both more sustainable and help to circumvent ethical dilemmas for maintenance of health in domestic dogs.

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“…Although a canine point‐of‐care NT‐proBNP assay is now available, to the author's knowledge there are not yet any published studies evaluating its effectiveness in clinical patients (Harr and others 2022); therefore, more research is needed before definitive recommendations can be made regarding how to use this test in practice.…”

Section: Differentiation Of Cardiac From Non‐cardiac Causes Of Respir...mentioning

confidence: 99%

Approach to dealing with acute heart failure in cats and dogs

Hezzell¹

2023

In Practice

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Background: Unfortunately, heart disease is common in both dogs and cats and may eventually result in congestive heart failure (CHF). However, the clinical signs of CHF overlap with other causes of respiratory compromise. As such, differentiating cardiac from non‐cardiac causes of respiratory distress is a common diagnostic challenge in emergency veterinary practice. The general principles of heart failure management can be applied to a broad range of cardiac diseases; identifying a cardiac cause for the clinical signs is therefore more important than making a definitive diagnosis in the acute phase of heart failure. Nevertheless, there is no ‘one‐size‐fits‐all’ recipe for treatment and the approach needs to be tailored to the individual (eg, severity of clinical signs, comorbidities, patient demeanour and so on). Although the information in this article is organised linearly, the approach to an emergency case seldom follows the structure used in more stable patients. For example, a dog or cat presenting with significant dyspnoea will typically require treatment (eg, supplementary oxygen ± light sedation) before physical examination and diagnostic testing, and some diagnostic tests may need to be postponed until the patient is stable enough to safely undergo them; therefore, the initial treatment plan is often based on a working, rather than a definitive, diagnosis. Aim of the article: This article provides an overview of the diagnosis and management of acute heart failure, highlighting similarities and differences between dogs and cats. The aim is to help practitioners approach these cases with more confidence.

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Analytical validation of a novel point‐of‐care immunoassay for canine N‐terminal pro‐brain natriuretic peptide analysis

Cited by 5 publications

References 20 publications

Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year

Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year

Domestic dogs maintain positive clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year

Approach to dealing with acute heart failure in cats and dogs

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