The nanoliquid flows place a significant role in modern research due to the vast number of applications in the Food industry, manufacturing, thermal management, enhanced oil recovery, biomedical applications, and so on. This article presents the analysis of entropy generation on convective nanofluid flow in a three-dimensional nonlinear stretching sheet with slip effects. Brownian motion and thermophoresis impacts are adopted by the nanoparticle concentration and temperature profiles. The PDEs are remodeled into ODEs by employing the appropriative simulated alternations, and the ODEs are solved by utilizing the R-K-F scheme along with the shooting technique. The main contributions of physical stream factors on the nanofluid concentration, heat, and speed profiles are displayed and explored via plots. Moreover, the rate of heat transfer and surface drag force are examined through tabular structures. In view of this, the nanofluids have more heat transfer capability and improve thermal properties. The slip factors are used in the boundary conditions of the velocity, and the limit conditions are utilized for the hotness and speed of the nanoparticles. The rate of heat transfer in a non-linear stretching sheet is 1%-2% more than linear stretching sheet for varying values of Prandtl number Pr and Magnetic field M.