Piezoelectric sensors and actuators have been widely used in many fields. In this study, the reliability of a piezoelectric actuator to alleviate the flutter of a flexible rectangular cantilever beam under wind load is investigated. Firstly, a dynamic calculation model of the cantilever beam underload is derived. Secondly, the derived dynamic calculation model of the cantilever beam is extended with a piezoelectric actuator. Thirdly, two types of wind load on the beam are considered. Finally, the reliability of using one and two actuators to alleviate the flutter of the beam under different wind loads is simulated. The proposed calculation model has practical engineering significance and feasibility for the reliability design and maintenance of unmanned aerial vehicle (UAV) wings and wind power devices.