Analytical silica monoliths with submicron macropores: Current limitations to a direct morphology–column efficiency scaling

Hormann, Kristof; Tallarek, Ulrich

doi:10.1016/j.chroma.2013.08.087

Cited by 39 publications

(68 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It approaches the champions league of capillary electrophoresis, where band broadening ideally occurs only due to diffusion along the longitudinal concentration gradient, independent of the band velocity. Regrettably, this outstanding performance seen in the simulations [33] is obscured in HPLC practice [32] by the column border effects. This includes the unoptimized (nonuniform) sample distribution and its asynchronous collection by the endfittings at the column inlet and outlet, respectively, and relegates further optimization from the material morphology and synthesis to a column hardware engineering problem (as known, in general, for short and/or wide columns).…”

Section: Examples Of Monoliths In Separation and Catalysismentioning

confidence: 96%

“…8 can the monolith offer with respect to the particulate core-shell packing? Indeed, there are a number of advantages, some of which are listed below [3,5,10,32,41,45,52,54]: (i) The monolith has a higher external surface area (cf. Fig.…”

Section: Advantages Of Monoliths Compared To Packed Bedsmentioning

confidence: 99%

“…In recent years, their preparation has been improved, culminating in the second generation of silica monoliths; with negligible radial heterogeneity and submicrometer macropore size, the second-generation monoliths show higher separation efficiencies [30 -33]. In addition to a radially homogeneous distribution of macroporosity, macropore size, and skeleton thickness [30], they realize smaller macropores at even increased macropore space homogeneity with respect to the first-generation monoliths [32]. Fig.…”

Section: Examples Of Monoliths In Separation and Catalysismentioning

confidence: 99%

“…Though pressure is still important, it can be easily managed with standard equipment and should not rule out small macropores if these help in a substantial process intensification, e.g., by avoiding costly downstream processing steps. Actually, a currently bigger challenge is the manufacture of a suitable cladding of the bare rods and a proper inlet and outlet design for homogeneous distribution and efficient collection of inlet and outlet streams, respectively, of the silica monolithic columns intended for use in solidliquid catalysis at elevated pressures [27,32,36,55].…”

Section: Silica-based Monoliths In Solid-liquid Catalysismentioning

confidence: 99%

See 3 more Smart Citations

Sol‐Gel and Porous Glass‐Based Silica Monoliths with Hierarchical Pore Structure for Solid‐Liquid Catalysis

Enke

Gläser

Tallarek

2016

Chemie Ingenieur Technik

Self Cite

View full text Add to dashboard Cite

This work draws attention to both prospects and challenges for silica monoliths in solid-liquid catalysis at ultrahigh efficiency. The fundamental advantages of silica monoliths as support structure over particulate fixed beds and organicpolymer monoliths are illustrated as well as recent applications as flow-through microreactors for the production of fine chemicals. Preparation routes to sol-gel and porous glass-based silica monoliths featuring a hierarchical pore structure are described and their potential use as short-contact-time reactors is highlighted together with a view on the multiscale characterization and their rational design by establishing quantitative synthesis-morphology-transport relationships.

show abstract

Section: Examples Of Monoliths In Separation and Catalysismentioning

confidence: 96%

Section: Advantages Of Monoliths Compared To Packed Bedsmentioning

confidence: 99%

Section: Examples Of Monoliths In Separation and Catalysismentioning

confidence: 99%

Section: Silica-based Monoliths In Solid-liquid Catalysismentioning

confidence: 99%

See 2 more Smart Citations

Sol‐Gel and Porous Glass‐Based Silica Monoliths with Hierarchical Pore Structure for Solid‐Liquid Catalysis

Enke

Gläser

Tallarek

2016

Chemie Ingenieur Technik

Self Cite

View full text Add to dashboard Cite

show abstract

“…[4][5][6] There are many reports of monolithic columns using silica, organic polymer, and hybrid inorganic-organic materials. [7][8][9][10][11][12][13] The application of monoliths has been extended from the original separation media to microreactors and solid phase extractors. [14][15][16] The utilization of monolithic capillary column with inner diameters of 75-250 µm is more preferred in miniaturized system and analysis, because such capillary columns are well-suited in the field of life sciences, which the amount of sample is limited.…”

Section: Introductionmentioning

confidence: 99%

"DEVELOPMENT OF Ti4+-IMMOBILIZED NANOPOROUS MONOLITHIC POLYMER FOR SELECTIVE SEPARATION AND DETECTION OF PHOSPHOPEPTIDES "

2018

RJC

View full text Add to dashboard Cite

Phosphopeptides present in a large number of biological regulating mechanisms. It plays a significant role in gene regulation, eukaryotic signal transduction, and metabolic control in a cell. Abnormal phosphorylation can cause various diseases, including cancer. However, phosphoprotein abundances are very low, only 1-2%. In this work, the nanoporous monolith columns were developed for separation and detection of phosphopeptides in phosphoproteome analysis. The nanoporous monolith-based column is prepared inside a silicosteel tubing (100 x 1.02 mm i.d.) by insitu copolymerization reaction of glycidyl methacrylate (GMA) with ethylene dimethacrylate (EDMA). This monolith was further chemically modified by introducing aminomethyl phosphonic acid (AMPA) before immobilization of Ti 4+ ion (Ti 4+ -immobilized). The monolithic column properties, such as morphology, elemental analysis, surface area analysis, permeability and pore distribution were characterized in detail. Such a Ti 4+ -immobilized nanoporous monolith-based column with immobilization time 3 hours of TiCl4 without glutaraldehyde addition was further applied to separation and detection of phosphopeptides from digested proteins (β-casein and cytochrome-c), and tyrosine phosphorylated peptide samples. The result demonstrated that Ti 4+ -immobilized nanoporous monolith-based provide higher selectivity and efficiency for selective detection of phosphopeptides using liquid chromatography.

show abstract

Assessing Structural Correlations and Heterogeneity Length Scales in Functional Porous Polymers from Physical Reconstructions

Müllner

Zankel

et al. 2015

Advanced Materials

Self Cite

View full text Add to dashboard Cite

A general, model-free, quantitative approach to the key morphological properties of a porous polymer monolith is presented. After 3D reconstruction, image-based analysis delivers detailed spatial and spatially correlated information on the structural heterogeneities in the void space and the polymer skeleton. Identified heterogeneities, which limit the monolith's performance in targeted applications, are traced back to the preparation process.

show abstract

Analytical silica monoliths with submicron macropores: Current limitations to a direct morphology–column efficiency scaling

Cited by 39 publications

References 73 publications

Sol‐Gel and Porous Glass‐Based Silica Monoliths with Hierarchical Pore Structure for Solid‐Liquid Catalysis

Sol‐Gel and Porous Glass‐Based Silica Monoliths with Hierarchical Pore Structure for Solid‐Liquid Catalysis

"DEVELOPMENT OF Ti4+-IMMOBILIZED NANOPOROUS MONOLITHIC POLYMER FOR SELECTIVE SEPARATION AND DETECTION OF PHOSPHOPEPTIDES "

Assessing Structural Correlations and Heterogeneity Length Scales in Functional Porous Polymers from Physical Reconstructions

Contact Info

Product

Resources

About