Analytical Review: Physiologic Control of Red Cell Production

The Influence of Environment on Iron Incorporation and Mitotic Division in a Suspension of Normal Bone Marrow*

“…It is generally accepted that tissue oxygen tension controls the rate of red-cell production (Erslev, 1955;Fried, Plzak, Jacobson and Goldwasser, 1957). The exact manner in which oxygen tension influences the marrow is not completely settled, but it appears that oxygen tension in the tissues regulates the production or release of an erythropoietic factor which in turn stimulates the proliferative activity of the erythropoietic tissue.…”

Proceedings of the Physiological Society, 20–21 September 1990, Belfast Meeting: Communications

“…We conclude that prolactin cells can express long and short forms of the D2 receptor; these may interact with different G proteins and thereby lead to the different electrophysiological responses. Erythropoietin, a circulating glycoprotein, is the principal humoral regulator of erythropoiesis (Erslev, 1955;Goldwasser, 1975). Normally it is present in the serum at picomolar concentration, but levels may rise up to 100-fold during severe hypoxic stress.…”

Factors Controlling Blood Volume

“…The role of the pituitary in erythropoiesis and the marrow stimulating ef€ect of plasma from bled animals (Erslev, 1955) has not been clarified.…”