Analytical review on the biocompatibility of surface-treated Ti-alloys for joint replacement applications

Jain, Shubham; Parashar, Vishal

doi:10.1080/17434440.2022.2132146

Cited by 12 publications

(4 citation statements)

References 125 publications

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“…Titanium alloys are favored by the orthopedic medical domains because of their good biocompatibility, high specific strength, and excellent corrosion resistance. 5 Compared to more biocompatible tantalum, titanium alloys have significant advantages in terms of processability and costs.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the need for load‐bearing bones to withstand large loads and complex stress environments, for example, the tibia bears the compression of the upper body during walking and standing, 4 so the bone scaffold material for load‐bearing bone repair are often metal materials. Titanium alloys are favored by the orthopedic medical domains because of their good biocompatibility, high specific strength, and excellent corrosion resistance 5 . Compared to more biocompatible tantalum, titanium alloys have significant advantages in terms of processability and costs.…”

Section: Introductionmentioning

confidence: 99%

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Customized 3D‐printed heterogeneous porous titanium scaffolds for bone tissue engineering

Fan,

Li,

et al. 2024

MedComm – Biomaterials and Applications

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Bone defect is a common clinical disease. Due to the uncertainty of trauma or infection areas, customized size features are often required for bone substitutes. By inspiration of the natural bone structure, this study designs porous scaffolds with a biomimetic design perspective by using different inner and outer pore units. The outer pore units adopt body‐centered cubic (BCC) structure to simulate the weight‐bearing function of human cortical bone, while inner pore units using I‐Wrapped Package structure, a kind of three periods minimum surface, to obtain a good permeability and simulates the inner layer of cancellous bone. To further regulate the overall modulus of the scaffold within the range of natural bone modulus in the human body, the scaffold was designed to axial gradient structure. Compression experiments were conducted, and the results indicated that when the volume fraction linearly increased from 20% to 50%, the Young's modulus was close to the cortical bone modulus in the human body. In vitro cell experiments further proved that osteoblasts have good cellular activity and spreading morphology on the surface of this scaffold. The customized 3D‐printed heterogeneous porous titanium scaffold has great application potential in bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Customized 3D‐printed heterogeneous porous titanium scaffolds for bone tissue engineering

Fan,

Li,

et al. 2024

MedComm – Biomaterials and Applications

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“…Metallic biomaterials such as tantalum (Ta), zirconium (Zr), titanium (Ti) and Ti alloys have been extensively used in clinical applications [1][2][3][4][5][6]. Especially in orthopedics and stomatology, advanced material preparation technology of the metal implants used in hard tissues keep reaching new efficacies for skeletal reconstructive surgery, recently referred to as "the operation of the century" [2].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Wear Behaviors of Monolayer and Heterogeneous Multilayer Ta Coatings in Atmospheric and SBF Environments

et al. 2023

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Monolayer Ta and multilayer Ti/Zr/Ta and Zr/Ti/Ta coatings were prepared by magnetron sputtering on TC4 substrates to improve the surface friction and wear properties in a simulated body fluid (SBF) environment and an atmospheric environment. Optical microscopy, scanning electron microscopy, laser scanning confocal microscopy and nano scratch testing were employed to establish the structure-property-environment relationships. By controlling the preparation parameters, the outermost layer of all three samples was Ta coating, and the total coating thickness of each sample was about 3 μm. Friction and wear testing revealed that, compared to bare TC4 substrate, and multilayer Ti/Zr/Ta and Zr/Ti/Ta coatings, the monolayer Ta possessed the lowest friction coefficient as well as the minimum wear rate (i.e., calculation result of the wear track width and wear depth). This was mainly attributed to excellent adhesion strength, a particular structure and solid lubrication of the monolayer coating. The same coating sample exhibited a stronger wear resistance in the SBF environment than in the atmospheric environment. Furthermore, the wear behaviors and mechanisms of various coatings under different experimental environments are also discussed.

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“…Notably, the material selection for these implants is not arbitrary; it is dictated by the need for mechanical compatibility with bone tissue. Therefore, materials with similar mechanical properties to bone tissue, such as metals and their alloysincluding stainless steel, cobalt, titanium, zirconium, and tantalum-have been the choice of preference [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Influence of Cu Substitution on the Properties of Hydroxyapatite Targets and Deposited Coatings

et al. 2023

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In addressing the issue of optimizing the mechanical and electrochemical properties of hydroxyapatite (CaP) materials for biomedical applications, this research explored the incorporation of copper (Cu) into the material and scrutinized its impact through various processing stages, from powders to ceramics and finally to coatings. Our investigation indicated that the integration of CuO into CaP significantly changed the lattice parameters of hydroxyapatite from manufactured powders to sintered targets, indicating a structural evolution. Simultaneously, the change in the elemental composition and Ca/P ratio was also followed by each step from manufactured powders to deposited coatings. Mechanical testing revealed an impressive increase in the hardness of coatings to a high of 37 GPa for the 0.2CuO-CaP sample, a substantial improvement when compared to 13 GPa for pure Ti. The corrosion resistance of the coatings also improved, evidenced by the decrease in corrosion current density (Icorr) from 60.2 ± 5.2 nA/cm2 for pure Ti to a lower 3.9 ± 0.5 nA/cm2 for the CaP coating. Our study has revealed that the structural, mechanical, and electrochemical properties of CaP materials can be finely adjusted through the addition of Cu, promising advances in the realm of biomedical applications. Moreover, these results hint at the potential to tune the electrophysical characteristics of CaP coatings, an avenue for future exploration.

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Analytical review on the biocompatibility of surface-treated Ti-alloys for joint replacement applications

Cited by 12 publications

References 125 publications

Customized 3D‐printed heterogeneous porous titanium scaffolds for bone tissue engineering

Customized 3D‐printed heterogeneous porous titanium scaffolds for bone tissue engineering

Comparative Study on Wear Behaviors of Monolayer and Heterogeneous Multilayer Ta Coatings in Atmospheric and SBF Environments

Influence of Cu Substitution on the Properties of Hydroxyapatite Targets and Deposited Coatings

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