Analytical modeling of multi-source content delivery in information-centric networks

Hashemi, Seyyed Naser Seyyed; Bohlooli, Ali

doi:10.1016/j.comnet.2018.05.007

Cited by 13 publications

(1 citation statement)

References 26 publications

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“…Three of these proteins are common to both HSA and CRP: 1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1), complement factor H (CFH), and fibronectin 1 (FN1). Some studies have shown details about CRP's relationship with AGPAT1 [64,65], but extensive studies have shown the details of CRP's interactions with CFH [66][67][68][69] and FN1 [70][71][72][73][74][75]. The specific location of these proteins interactions with HSA is less understood.…”

Section: Plos Onementioning

confidence: 99%

Modification of the structural stability of human serum albumin in rheumatoid arthritis

et al. 2023

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Differential scanning calorimetry (DSC) can indicate changes in structure and/or concentration of the most abundant proteins in a biological sample via heat denaturation curves (HDCs). In blood serum for example, HDC changes result from either concentration changes or altered thermal stabilities for 7–10 proteins and has previously been shown capable of differentiating between sick and healthy human subjects. Here, we compare HDCs and proteomic profiles of 50 patients experiencing joint-inflammatory symptoms, 27 of which were clinically diagnosed with rheumatoid arthritis (RA). The HDC of all 50 subjects appeared significantly different from expected healthy curves, but comparison of additional differences between the RA and the non-RA subjects allowed more specific understanding of RA samples. We used mass spectrometry (MS) to investigate the reasons behind the additional HDC changes observed in RA patients. The HDC differences do not appear to be directly related to differences in the concentrations of abundant serum proteins. Rather, the differences can be attributed to modified thermal stability of some fraction of the human serum albumin (HSA) proteins in the sample. By quantifying differences in the frequency of artificially induced post translational modifications (PTMs), we found that HSA in RA subjects had a much lower surface accessibility, indicating potential ligand or protein binding partners in certain regions that could explain the shift in HSA melting temperature in the RA HDCs. Several low abundance proteins were found to have significant changes in concentration in RA subjects and could be involved in or related to binding of HSA. Certain amino acid sites clusters were found to be less accessible in RA subjects, suggesting changes in HSA structure that may be related to changes in protein-protein interactions. These results all support a change in behavior of HSA which may give insight into mechanisms of RA pathology.

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Section: Plos Onementioning

confidence: 99%

Modification of the structural stability of human serum albumin in rheumatoid arthritis

et al. 2023

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Analytical characterization of cache replacement policy impact on content delivery time in information‐centric networks

Hashemi

Bohlooli

2019

Int J Communication

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Summary Information‐centric networking (ICN) has emerged as a promising candidate for designing content‐based future Internet paradigms. ICN increases the utilization of a network through location‐independent content naming and in‐network content caching. In routers, cache replacement policy determines which content to be replaced in the case of cache free space shortage. Thus, it has a direct influence on user experience, especially content delivery time. Meanwhile, content can be provided from different locations simultaneously because of the multi‐source property of the content in ICN. To the best of our knowledge, no work has yet studied the impact of cache replacement policy on the content delivery time considering multi‐source content delivery in ICN, an issue addressed in this paper. As our contribution, we analytically quantify the average content delivery time when different cache replacement policies, namely, least recently used (LRU) and random replacement (RR) policy, are employed. As an impressive result, we report the superiority of these policies in term of the popularity distribution of contents. The expected content delivery time in a supposed network topology was studied by both theoretical and experimental method. On the basis of the obtained results, some interesting findings of the performance of used cache replacement policies are provided.

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Cloud System for Distributing Multimedia Content in Cyber-Physical Systems

Levonevskiy

Saveliev

Duboyskiy

et al. 2019

Cyber-Physical Systems and Control

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Analytical modeling of multi-source content delivery in information-centric networks

Cited by 13 publications

References 26 publications

Modification of the structural stability of human serum albumin in rheumatoid arthritis

Modification of the structural stability of human serum albumin in rheumatoid arthritis

Analytical characterization of cache replacement policy impact on content delivery time in information‐centric networks

Cloud System for Distributing Multimedia Content in Cyber-Physical Systems

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