Analytical Methods of Some Calcium Channel Blockers. A Brief Review.

Abstract

Calcium channel blockers (CCBs) are a class of pharmaceutical compounds frequently used to treat a variety of cardiovascular and neurological problems. For such drugs to be therapeutically effective and patient-safe, their exact and accurate determination is essential. A detailed description of the analytical methods used to determine three of the calcium channel blockers, namely, lercanidipine, Nimodipine and Nifedipineis provided in a brief review article with 100 references. It includes a thorough review of research articles published up to September 2023. High-performance liquid chromatography, gas chromatography, electrochemical, capillary electrophoresis and spectroscopic techniques including UV-Visible and spectrofluorometry are only a few of the analytical methods covered in the paper. These techniques provide excellent CCB quantification in a variety of matrices with high sensitivity, specificity, and reproducibility. In order to perform precise and reliable analysis of these CCBs, the research emphasizes the significance of sample preparation procedures, extraction methodologies, and validation criteria. Additionally, it explores current developments in analytical instrumentation and how they can be used to analyze lercanidipine, nimodipine, and nifedipine.