Analytical methods, occurrence and trends of tropane alkaloids and calystegines: An update

Romera-Torres, Ana; Romero-González, Roberto; Vidal, José Luis Martı́nez; Frenich, Antonia Garrido

doi:10.1016/j.chroma.2018.06.004

Cited by 42 publications

(21 citation statements)

References 57 publications

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“…The concentrations of tropane alkaloids vary depending on the Brugmansia or Datura species, seasons of the year and the plant parts involved in the exposure [16,17,19,46]. The ratio of scopolamine and atropine in various plant organs was found to be species dependent, e.g., in D. innoxia, scopolamine was found to be predominant in all plant organs, while atropine levels were found to be higher as compared to scopolamine in leaf samples of D. metel [17].…”

Section: Poisoning Potential Of Various Plant Parts Of Brugmansia Andmentioning

confidence: 97%

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Worldwide poisoning potential of Brugmansia and Datura

Kerchner

Farkas

2019

Forensic Toxicol

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Purpose The toxicological significance of human exposures to angel's trumpet plants (Brugmansia and Datura species) in their native American and non-native regions (Asia, Africa, and Europe) was highlighted, and the poisoning potential of various plant parts was discussed. Methods Nearly 2500 cases of human plant exposures, reported to the Hungarian Toxicological Information Service between 2005 and 2017, were analyzed and compared to data of other toxicology centers in America, Asia and Europe, focusing on exposures to tropane alkaloid-containing plants. Results In America, Brugmansia and Datura were not among the 15 most common plant ingestions, but were responsible for 20% of the fatal outcomes in a 26-year period. In Asia, the anticholinergic toxidrome, related to Brugmansia and Datura, was among the most frequent plant-related intoxications, which included accidental ingestion, improper use of herbal medicines and plant abuse. In Europe, Brugmansia and Datura were among the top four plant taxa causing intoxications with major outcomes, being the leading plants ingested for their hallucinogenic properties, and accounted for 60% of abuse cases in Hungary in a 13-year period. Use of Brugmansia and Datura for criminal purposes has been reported from America, Asia and Europe. The concentrations of tropane alkaloids vary with the species, seasons and plant parts. Ingestion of the seeds and flowers has the highest toxicological significance, but exposure to the leaves and floral nectar can also cause intoxication. Conclusions Angel's trumpets have high toxicological significance both in their native and non-native regions, mainly due to their hallucinogenic property and accidental ingestion.

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Section: Poisoning Potential Of Various Plant Parts Of Brugmansia Andmentioning

confidence: 97%

“…Both Brugmansia and Datura species are considered toxic, due to the presence of the tropane alkaloids atropine and scopolamine in each plant organ [11][12][13][14][15][16][17][18][19]. Atropine is known for its anticholinergic activity, causing mydriasis, blurred vision, suppressed salivation, vasodilation, tachycardia and delirium [20].…”

Section: Introductionmentioning

confidence: 99%

Worldwide poisoning potential of Brugmansia and Datura

Kerchner

Farkas

2019

Forensic Toxicol

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“…The EFSA is currently demanding more information and studies about the presence of these toxic compounds in food in order to know the real exposure of the population to these toxins through their intake because of their potential harmful risks to human health [4,[7][8][9][10][11][12]. In this sense, in recent years, several analytical methods have been proposed to identify and quantify these compounds in different food samples [82][83][84]. However, most of these methods employ commercial materials as sorbents and, in addition, none of them have been performed under microextraction conditions.…”

Section: Future Challenges In the Integration Of New Advanced Materiamentioning

confidence: 99%

New Advanced Materials and Sorbent-Based Microextraction Techniques as Strategies in Sample Preparation to Improve the Determination of Natural Toxins in Food Samples

2020

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Natural toxins are chemical substances that are not toxic to the organisms that produce them, but which can be a potential risk to human health when ingested through food. Thus, it is of high interest to develop advanced analytical methodologies to control the occurrence of these compounds in food products. However, the analysis of food samples is a challenging task because of the high complexity of these matrices, which hinders the extraction and detection of the analytes. Therefore, sample preparation is a crucial step in food analysis to achieve adequate isolation and/or preconcentration of analytes and provide suitable clean-up of matrix interferences prior to instrumental analysis. Current trends in sample preparation involve moving towards “greener” approaches by scaling down analytical operations, miniaturizing the instruments and integrating new advanced materials as sorbents. The combination of these new materials with sorbent-based microextraction technologies enables the development of high-throughput sample preparation methods, which improve conventional extraction and clean-up procedures. This review gives an overview of the most relevant analytical strategies employed for sorbent-based microextraction of natural toxins of exogenous origin from food, as well as the improvements achieved in food sample preparation by the integration of new advanced materials as sorbents in these microextraction techniques, giving some relevant examples from the last ten years. Challenges and expected future trends are also discussed.

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“…However, they have an adverse effect on public health when overdosed. This may be caused by tropane alkaloids (TAs), which are synthesized by most plants from nightshade family [6]. Overdose of atropine gives rise to seizures, pupil dilatation, disturbance of vision, and arrhythmias [7].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of three tropane alkaloids in goji berries by cleanup of the graphene/hexagonal boron nitride hybrids and ultra‐high‐performance liquid chromatography tandem mass spectrometry

Zhao

Shi

2020

J of Separation Science

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A modified quick, easy, cheap, effective, rugged and safe method was established for simultaneous determination of atropine, anisodamine, and scopolamine in goji berries by using ultra‐high‐performance liquid chromatography with tandem mass spectrometry. The graphene/hexagonal boron nitride hybrids were prepared and first applied as a cleanup adsorbent. Compared to classical cleanup adsorbent (C18), the graphene/hexagonal boron nitride hybrids as adsorbent had better extraction efficiency for the detection of analytes. Under the optimal conditions, the proposed analytical method achieved satisfactory linearity (R2 > 0.995), and obtained desirable recoveries ranged from 77.4 to 94.0% with the relative standard deviation of 1.2–6.1% at the concentration levels of 3.2–13.4 µg/kg. The limits of quantitation of atropine, anisodamine, and scopolamine were, respectively, 3.2, 4.6, and 4.5 µg/kg with linearity ranged from 3.2 to 25.4 µg/kg. The modified quick, easy, cheap, effective, rugged, and safe sample preparation with ultra‐high‐performance liquid chromatography and tandem mass spectrometry method was successfully applied to evaluate the safety of goji berries collected from 30 plant areas in China, suggesting its applicability and suitability for the routine analysis of three tropane alkaloids in goji berries.

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Analytical methods, occurrence and trends of tropane alkaloids and calystegines: An update

Cited by 42 publications

References 57 publications

Worldwide poisoning potential of Brugmansia and Datura

Worldwide poisoning potential of Brugmansia and Datura

New Advanced Materials and Sorbent-Based Microextraction Techniques as Strategies in Sample Preparation to Improve the Determination of Natural Toxins in Food Samples

Simultaneous quantification of three tropane alkaloids in goji berries by cleanup of the graphene/hexagonal boron nitride hybrids and ultra‐high‐performance liquid chromatography tandem mass spectrometry

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