Analytical methods in resorbable polymer development and degradation tracking

Rizzarelli, Paola; Carta, Stefania La; Rapisarda, Marco; Valenti, Graziella

doi:10.1016/b978-0-12-818415-8.00013-9

Cited by 3 publications

(6 citation statements)

References 244 publications

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“…Size‐exclusion chromatography (SEC) and MS techniques are currently applied to determine the molar mass (MM) and check the structural changes induced by the degradation source in the polymer samples . Several MS methods have been adopted for the structural characterization of biodegradable polymers . Checking the structure, purity and defects in this kind of polymers requires good analytical characterization techniques above all for detection of trace amounts and it is crucial as a guarantee of safety, efficiency and quality.…”

Section: Characterization Of Bioresorbable Polymers By Msmentioning

confidence: 99%

“…In particular, the synthetic hydrogels possess a tunable chemical composition and 3D physical structure that enable the mechanical properties, biodegradation, and biocompatibility to be controlled. In the literature, there are several studies addressed to the synthesis, characterization, citocompatibility and degradation of hydrogels based on biodegradable moieties . Bencherif et al synthesized a series of resorbable hydrogels by crosslinking polymerization of PEG‐ co ‐PGA macromonomers containing three types of end‐group functionalities: diacrylates, dimethacrylates, and urethane dimethacrylates.…”

Section: Characterization Of Bioresorbable Polymers By Msmentioning

confidence: 99%

“…It is noteworthy that progress in organic synthesis and characterization methods has yielded synthetic bioresorbable polymers with well‐defined, three‐dimensional (3D) structures and with the prospect of mimicking biomacromolecules. These well‐structured polymers include block copolymers, branched, dendritic, graft and star‐shaped polymers . In addition, reliable design of the polymer synthetic methods allows tailoring of the mechanical, physicochemical and degradation properties or drug‐release kinetics of the resulting materials.…”

Section: Introductionmentioning

confidence: 99%

“…Mass spectrometry (MS) has played an increasingly important role in polymer analysis, thanks also to the improvement in instrumental techniques and the introduction of up‐to‐date configurations. In recent times, several reviews, books, and book chapters on modern MS in polymer chemistry have been published. Undoubtedly, modern MS methods, with their high sensitivity, selectivity, and rapidity, provide the opportunity to look at the finest structural details even in complex polymer samples, and provide valuable support for the whole characterization of bioresorbable polymeric materials.…”

Section: Introductionmentioning

confidence: 99%

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Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Rizzarelli

Rapisarda

Valenti

2020

Rapid Comm Mass Spectrometry

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A detailed characterization of polymeric matrices and appropriate degradation monitoring techniques are required to sustain the development of new materials as well as to enlarge the applications of the old ones. In fact, polymer analysis is essential for the clarification of the intrinsic relationship between structure and properties that ascertains the industrial applications in diverse fields. In bioresorbable and biodegradable polymers, the role of analytical methods is dual since it is pointed both at the polymeric matrices and at degradation tracking. The structural architectures, the mechanical and morphological properties, and the degradation rate, are of outstanding importance for a specific application. In some cases, the complexity of the polymer structure, the processes of decomposition or the low concentration of the degradation products need the concurrent use of different complementary analytical techniques to give detailed information of the reactions taking place. Several analytical methods are used in bioresorbable polymer development and degradation tracking. Among them, mass spectrometry (MS) plays an essential role and it is used to refine polymer syntheses, for its high sensitivity, to highlight degradation mechanism by detecting compounds present in trace amounts, or to track the degradation product profile and to study drug release. In fact, elucidation of reaction mechanisms and polymer structure, attesting to the purity and detecting defects as well as residual catalysts, in biodegradable and bioresorbable polymers, requires sensitive analytical characterization methods that are essential in providing an assurance of safety, efficacy and quality. This review aims to provide an overview of the MS strategies used to support research and development of resorbable polymers as well as to investigate their degradation mechanisms. It is focused on the most significant studies concerning synthetic bioresorbable matrices (polylactide, polyglycolide and their copolymers, polyhydroxybutyrate, etc.), published in the last ten years.

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Section: Characterization Of Bioresorbable Polymers By Msmentioning

confidence: 99%

Section: Characterization Of Bioresorbable Polymers By Msmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Rizzarelli

Rapisarda

Valenti

2020

Rapid Comm Mass Spectrometry

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“…More recently, several studies have been focused on DDS and pharmacokinetics by MS/MS, thanks to the technological progress and combining ESI with separation techniques. Overall, MS has been more extensively employed in the analyses of biodegradable polymers [ 14 , 15 , 16 , 19 , 21 , 23 , 25 , 28 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 44 , 128 ] than tandem MS [ 38 , 39 , 40 , 41 , 42 , 43 , 45 ], even if MS/MS is highly informative. This should be reasonably due to the time-consuming step related to the data processing and interpretation in MS/MS [ 14 , 15 , 19 , 28 , 39 , 42 ], even though tandem MS analysis has provided valuable information on biodegradable polymer architectures, end-group functionalities, bond connectivity, copolymer sequences, etc.…”

Section: Introductionmentioning

confidence: 99%

Matrix-Assisted Laser Desorption and Electrospray Ionization Tandem Mass Spectrometry of Microbial and Synthetic Biodegradable Polymers

Rizzarelli

Rapisarda

2023

Polymers

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The in-depth structural and compositional investigation of biodegradable polymeric materials, neat or partly degraded, is crucial for their successful applications. Obviously, an exhaustive structural analysis of all synthetic macromolecules is essential in polymer chemistry to confirm the accomplishment of a preparation procedure, identify degradation products originating from side reactions, and monitor chemical–physical properties. Advanced mass spectrometry (MS) techniques have been increasingly applied in biodegradable polymer studies with a relevant role in their further development, valuation, and extension of application fields. However, single-stage MS is not always sufficient to identify unambiguously the polymer structure. Thus, tandem mass spectrometry (MS/MS) has more recently been employed for detailed structure characterization and in degradation and drug release monitoring of polymeric samples, among which are biodegradable polymers. This review aims to run through the investigations carried out by the soft ionization technique matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and electrospray ionization mass spectrometry (ESI-MS) MS/MS in biodegradable polymers and present the resulting information.

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Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

Rizzarelli,

Leanza,

Rapisarda

2023

Mass Spectrometry Reviews

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Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market. Therefore, additional research efforts are required to improve their performance. Mass spectrometry (MS) affords a relevant contribution to optimize biodegradable polymer synthesis, to confirm macromolecular structures, to examine along the time the progress of degradation processes and highlight advantages and drawbacks in the extensive applications. This review aims to provide an overview of the MS investigations carried out to support the synthesis of biodegradable polymers, with helpful information on undesirable products or polymerization mechanism, to understand deterioration pathways by the structure of degradation products and to follow drug release and pharmacokinetic. Additionally, it summarizes MS studies addressed on environmental and health issues related to the extensive use of plastic materials, that is, potential migration of additives or microplastics identification and quantification. The paper is focused on the most significant studies relating to synthetic and microbial biodegradable polymers published in the last 15 years, not including agro‐polymers such as proteins and polysaccharides.

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Analytical methods in resorbable polymer development and degradation tracking

Cited by 3 publications

References 244 publications

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Mass spectrometry in bioresorbable polymer development, degradation and drug‐release tracking

Matrix-Assisted Laser Desorption and Electrospray Ionization Tandem Mass Spectrometry of Microbial and Synthetic Biodegradable Polymers

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

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