Analytical Methods for the Quantification of Bisphenol A, Alkylphenols, Phthalate Esters, and Perfluoronated Chemicals in Biological Samples

Nakazawa, Hiroyuki; Iwasaki, Yusuke; Ito, Rie

doi:10.2116/analsci.30.25

Cited by 21 publications

(21 citation statements)

References 121 publications

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“…Abbreviations of the chemicals are shown in Table . Concentrations of phthalates (MEHP and DEHP), PFCs (PFHxS, PFOS, PFNA, and PFOA), bisphenol A, nicotines (NIC, NNIC, COT, NCOT, and HCOT), and PBDEs were determined as we previously reported …”

Section: Methodsmentioning

confidence: 99%

Evidence of exposure to chemicals and heavy metals during pregnancy in Japanese women

Maekawa

Ito

Iwasaki

et al. 2017

Reprod Medicine & Biology

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PurposePrenatal exposure to environmental chemicals is a growing concern, because such exposures have been shown to be associated with various diseases. The levels of chemicals and heavy metals in maternal blood, cord blood, maternal urine and amniotic fluid in Japanese pregnant women were investigated.MethodsA total of 145 women, including 14 fetal growth restriction cases, were included in the present study. The levels of phthalates (di[2‐ethylhexyl]phthalate and mono[2‐ethylhexyl]phthalate), perfluorinated compounds (perfluorooctane sulfonate, perfluorohexanoic acid, perfluorooctanoic acid, and perfluorononanoic acid), pesticides (dimethylphosphate, dimethylthiophosphate, diethylphosphate, diethylthiophosphate, 3‐phenoxybenzoic acid, and octachlorodipropyl ether), bisphenol A, nicotine (nicotine, nornicotine, cotinine, norcotinine, and trans‐3’‐hydroxycotinine), polybrominated diphenyl ethers, and heavy metals were measured. The relationship between fetal growth and the levels of chemicals and heavy metals were investigated.ResultsPhthalates, perfluorinated compounds, pesticides, polybrominated diphenyl ethers, and heavy metals were detected in high frequency, whereas nicotine and bisphenol A were almost negative. Phthalates, perfluorinated compounds, and several heavy metals were transferred to the fetus. High perfluorononanoic acid levels in the maternal blood and cord blood, and low perfluorooctanoic acid level in the cord blood were significantly and negatively associated with fetal growth.ConclusionsThe present study showed that pregnant women in Japan and their fetuses are exposed to a variety of chemicals and heavy metals.

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Section: Methodsmentioning

confidence: 99%

Evidence of exposure to chemicals and heavy metals during pregnancy in Japanese women

Maekawa

Ito

Iwasaki

et al. 2017

Reprod Medicine & Biology

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“…At present, common analytical methods of PAEs are based on GC , GC–MS , LC , LC–MS/MS , IR or FFTIR spectroscopy , fluorescence spectroscopy , and ELISA . Spectroscopy methods and chromatography methods have limitations in many practical applications with long testing time and high detection cost.…”

Section: Introductionmentioning

confidence: 99%

“…They are extensively used as plasticizers for polymers such as poly(vinyl chloride), polystyrene (PS), and polyethylene in plastics industries [1,2]. The PAEs At present, common analytical methods of PAEs are based on GC [13], GC-MS [14][15][16], LC [17], LC-MS/MS [18,19], IR or FFTIR spectroscopy [20], fluorescence spectroscopy [9], and ELISA [21]. Spectroscopy methods and chromatography methods have limitations in many practical applications with long testing time and high detection cost.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of 22 phthalate esters in polystyrene food‐contact materials by ultra‐performance convergence chromatography with tandem mass spectrometry

Fan

Cui

et al. 2018

J of Separation Science

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A method for the determination of 22 phthalate esters in polystyrene food-contact materials has been established using ultraperformance convergence chromatography with tandem mass spectrometry. In this method, 22 phthalate esters were analyzed in <3.5 min on an ACQUITY Tours 1-AA column by gradient elution. The mobile phase, the compensation solvent, the flow rate of mobile phase, column temperature, and automatic back pressure regulator pressure were optimized, respectively. There was a good linearity of 20 phthalate esters with a range of 0.05-10 mg/L, diisodecyl phthalate and diisononyl phthalate were 0.25-10 mg/L, and the correlation coefficients of all phthalates were higher than 0.99 and those of 16 phthalates were higher than 0.999. The limits of detection and the limits of quantification of 15 phthalates were 0.02 and 0.05 mg/kg, meanwhile diallyl phthalate, diisobutyl phthalate, dimethyl phthalate, di-n-butyl phthalate, and di(2-ethylhexyl) phthalate were 0.05 and 0.10 mg/kg, and diisodecyl phthalate and diisononyl phthalate were 0.10 and 0.25 mg/kg. The spiked recoveries were in the range of 76.26-107.76%, and the relative standard deviations were in the range of 1.78-12.10%. Results support this method as an efficient alternative to apply for the simultaneous determination of 22 phthalate esters in common polystyrene food-contact materials.

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“…1,2 Due to its widespread use, residues of BPA have been often detected in water, soil, air, medical devices and foods. [3][4][5][6][7] BPA, which is one of the most representative compounds of environmental endocrine disrupting chemicals (EDCs), causes cardiovascular disease, diabetes, neuro-behavioral disorders, carcinogenic hypersensitivity, and reproductive impairment, even at low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Investigation of 1-Dodecylimidazolinm Modified Filter Papers as a Thin-Film Microextraction Phase for the Preconcentration of Bisphenol A from Plant Oil Samples

Liu

Wang

et al. 2017

ANAL. SCI.

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Based on the tunability of ionic liquids (ILs) according to the specific requirement of an application, 1-dodecylimidazolium chloride with amphiphilic structures was chemically fabricated on the surface of filter papers (DIL-FPs) for the first time. After synthesis, DIL-FPs was characterized by scanning electronic microscopy, energy dispersive X-ray spectroscopy and Fourier-transform infrared spectroscopy. DIL-FPs was used as a novel thin-film microextraction (TFME) phase for the preconcentration of amphiphilic bisphenol A from plant oil samples. The related extraction variables were studied in a spiked sunflower seed oil. Under the optimal conditions, the linear range was 5.0 -1000 μg L -1 with a correlation coefficient of 0.9976. The limit of detection (S/N = 3) and the enrichment factor of the proposed method were 2.7 μg L -1 and 118, respectively. The intra-day precision and inter-day precision for six repeated determinations were 2.3 and 4.9%, respectively. These plant oil samples used in this work were free of bisphenol A contaminations. The recovery study carried out in different plant oil samples and mean recoveries ranged from 77.16 to 97.10%. The developed DIL-FPs extraction film phase followed by HPLC-UV provides a potential pretreatment strategy for the analysis of weak organic acid compounds in plant oil samples.

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Analytical Methods for the Quantification of Bisphenol A, Alkylphenols, Phthalate Esters, and Perfluoronated Chemicals in Biological Samples

Cited by 21 publications

References 121 publications

Evidence of exposure to chemicals and heavy metals during pregnancy in Japanese women

Evidence of exposure to chemicals and heavy metals during pregnancy in Japanese women

Simultaneous determination of 22 phthalate esters in polystyrene food‐contact materials by ultra‐performance convergence chromatography with tandem mass spectrometry

Investigation of 1-Dodecylimidazolinm Modified Filter Papers as a Thin-Film Microextraction Phase for the Preconcentration of Bisphenol A from Plant Oil Samples

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