Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride

Teshima, Koichiro; Kondo, Takahiro

doi:10.1016/j.jpba.2008.01.032

Cited by 17 publications

(9 citation statements)

References 16 publications

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“…An anhydride has two acyl groups bound to the same oxygen atom and could serve as a source of reactive acyl groups to react with -NH 2 and -OH. Acetic anhydride (Berdyshev et al, 2005), benzoic anhydride, propionic anhydride (Nordstrom et al, 2004), DATAN (Struys et al, 2004), trimellitic anhydride, and 3-nitrophthalic anhydride (Teshima & Kondo, 2008) are most-commonly used (Fig. 14).…”

Section: Derivatization-based Lc-msmentioning

confidence: 99%

“…A 3-nitrophthalic anhydride derivatization-based LC-ESI-MS/MS method was developed to simultaneously determine farnesol and geranylgeraniol in rat liver and testis. These two metabolites are believed to play a physiological role in the regulated proteolysis of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (Teshima & Kondo, 2008).…”

Section: Other Biomarkersmentioning

confidence: 99%

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Enhancement of the capabilities of liquid chromatography–mass spectrometry with derivatization: General principles and applications

Zou

Liu

et al. 2011

Mass Spectrometry Reviews

134

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The integration of liquid chromatography-mass spectrometry (LC-MS) with derivatization is a relatively new and unique strategy that could add value and could enhance the capabilities of LC-MS-based technologies. The derivatization process could be carried out in various analytical steps, for example, sampling, storage, sample preparation, HPLC separation, and MS detection. This review presents an overview of derivatization-based LC-MS strategy over the past 10 years and covers both the general principles and applications in the fields of pharmaceutical and biomedical analysis, biomarker and metabolomic research, environmental analysis, and food-safety evaluation. The underlying mechanisms and theories for derivative reagent selection are summarized and highlighted to guide future studies.

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Section: Derivatization-based Lc-msmentioning

confidence: 99%

Section: Other Biomarkersmentioning

confidence: 99%

Enhancement of the capabilities of liquid chromatography–mass spectrometry with derivatization: General principles and applications

Zou

Liu

et al. 2011

Mass Spectrometry Reviews

134

View full text Add to dashboard Cite

show abstract

“…The generated derivatives gave the product ion at m/z 166 by CID. The transitions of [M − H] ‐ to m/z 166 were monitored (Teshima and Kondo, 2008).…”

Section: Derivatization Reagentsmentioning

confidence: 99%

Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry

Santa

2010

Biomedical Chromatography

163

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Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI-MS/MS is presented, focusing on the applications to low molecular weight compounds.

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“…stm.sciencemag.org/cgi/content/full/13/604/eaax8891/DC1 Materials and Methods Figs. S1 to S11 Tables S1 to S6 Movies S1 to S3 Data file S1 References (46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60) View/request a protocol for this paper from Bio-protocol.…”

Section: Supplementary Materialsmentioning

confidence: 99%

PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease

Lee

Kam

et al. 2021

Sci. Transl. Med.

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Accumulation of the parkin-interacting substrate (PARIS; ZNF746), due to inactivation of parkin, contributes to Parkinson’s disease (PD) through repression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α; PPARGC1A) activity. Here, we identify farnesol as an inhibitor of PARIS. Farnesol promoted the farnesylation of PARIS, preventing its repression of PGC-1α via decreasing PARIS occupancy on the PPARGC1A promoter. Farnesol prevented dopaminergic neuronal loss and behavioral deficits via farnesylation of PARIS in PARIS transgenic mice, ventral midbrain transduction of AAV-PARIS, adult conditional parkin KO mice, and the α-synuclein preformed fibril model of sporadic PD. PARIS farnesylation is decreased in the substantia nigra of patients with PD, suggesting that reduced farnesylation of PARIS may play a role in PD. Thus, farnesol may be beneficial in the treatment of PD by enhancing the farnesylation of PARIS and restoring PGC-1α activity.

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Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride

Cited by 17 publications

References 16 publications

Enhancement of the capabilities of liquid chromatography–mass spectrometry with derivatization: General principles and applications

Enhancement of the capabilities of liquid chromatography–mass spectrometry with derivatization: General principles and applications

Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry

PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease

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