Analytical expression for electric field between two facing strip electrodes in microchannel

Linderholm, Pontus; Seger, Urban; Renaud, Philippe

doi:10.1049/el:20063326

Cited by 15 publications

(15 citation statements)

References 8 publications

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“…At each discrete frequency, the S decreases with increasing w/h. In contrast [31], there is no optimal ratio of the electrode width to channel height. These results show that the impedance change is greater for larger volume fractions, that is smaller detection volume (smaller electrode width for fixed length and channel height), as the size of the cell is fixed.…”

Section: Impedance Sensitivitymentioning

confidence: 99%

“…The sensitivity of Design A (parallel facing electrodes) has been discussed by Linderholm et al [31]. These authors defined the sensitivity as the ratio of local power dissipation to total power dissipated in the medium, effectively related to the electric field magnitude squared and the cell constant of the device.…”

Section: Impedance Sensitivitymentioning

confidence: 99%

“…These authors applied a subsequent sine and bilinear transformation [30] to perform the conformal mapping, and derived an accurate value for the cell constant which gave good correlation with the published experimental values of electrolyte conductivity. Later, Linderholm et al [31] derived the analytical solution for electric field between two parallel facing electrodes using the similar procedure. More recently, Demierre et al [32] utilised the method in the work of Linderholm and Renaud [30] to derive the electric field distribution in a micro-device for the dielectrophoretic manipulation of particles.…”

Section: Introductionmentioning

confidence: 99%

“…The sine transformation can also be easily derived using SCM (see Section 7.1) In this paper, we present a general method for the derivation of the electric field distribution for two different designs of micro-cytometers, based on SCM. Compared to the derivations [30][31][32], no sine transformation or bilinear transformation is needed, making the derivations systematic and straightforward. In the analytical solutions, the salient features of the electric field distribution can be clearly associated with the geometrical parameters of the cytometer.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs

Sun

Green

Gawad

et al. 2007

IET Nanobiotechnol.

112

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Microfabricated impedance cytometers have been developed to measure the electrical impedance of single biological particles at high speed. A general approach to analytically solve the electric field distributions for two different designs of cytometers: parallel facing electrodes and coplanar electrodes, using the Schwarz -Christoffel Mapping method is presented. Compared to previous analytical solutions, our derivations are more systematic and solutions are more straightforward. The solutions have been validated by comparison with numerical simulations performed using the finite element method. The influences on the electric field distribution due to the variations in the geometry of the devices have been discussed. A simple method is used to determine the impedance sensitivity of the system and to compare the two electrode designs. For identical geometrical parameters, we conclude that the parallel electrodes design is more sensitive than the coplanar electrodes.

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Section: Impedance Sensitivitymentioning

confidence: 99%

Section: Impedance Sensitivitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs

Sun

Green

Gawad

et al. 2007

IET Nanobiotechnol.

112

View full text Add to dashboard Cite

show abstract

“…Using this technique, the analytical expressions developed are design-specific [12][13][14]. The microchannel structure under consideration has a uniform cross-section throughout its length, and the electrodes are placed at both terminals of the microchannel.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Electric Fields inside Microchannels and Single Cell Electrical Lysis with a Microfluidic Device

2013

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Analysis of electric fields generated inside the microchannels of a microfluidic device for electrical lysis of biological cells along with experimental verification are presented. Electrical lysis is the complete disintegration of cell membranes, due to a critical level of electric fields applied for a critical duration on a biological cell. Generating an electric field inside a microchannel of a microfluidic device has many advantages, including the efficient utilization of energy and low-current requirement. An ideal microchannel model was compared with a practical microchannel model using a finite element analysis tool that suggests that the overestimation error can be over 10%, from 2.5 mm or smaller, in the length of a microchannel. Two analytical forms are proposed to reduce this overestimation error. Experimental results showed that the high electric field is confined only inside the microchannel that is in agreement with the simulation results. Single cell electrical lysis was conducted with a fabricated microfluidic device. An average of 800 V for seven seconds across an 8 mm-long microchannel with the dimension of 100 μm × 20 μm was required for lysis, with electric fields exceeding 100 kV/m and consuming 300 mW.

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Dielectrophoresis as a Cell Characterisation Tool

Hoettges

2009

Methods in Molecular Biology

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Analytical expression for electric field between two facing strip electrodes in microchannel

Cited by 15 publications

References 8 publications

Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs

Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs

Analysis of Electric Fields inside Microchannels and Single Cell Electrical Lysis with a Microfluidic Device

Dielectrophoresis as a Cell Characterisation Tool

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