Analytical Currents: Helping diabetics avoid the needle

Bradley, David

doi:10.1021/ac9717090

Cited by 2 publications

(2 citation statements)

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“…Since this study, many papers dealing with enzyme-based biosensors have been published in the literature. [2][3][4][5][6] Because of its importance in the human metabolism, glucose is the most studied analyte. 7 Indeed, the development of a stable in vivo sensor could improve the regulation of glucose concentration and reduce complications related to diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Direct One-Step Immobilization of Glucose Oxidase in Well-Ordered Mesostructured Silica Using a Nonionic Fluorinated Surfactant

et al. 2005

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This work describes the immobilization of glucose oxidase (GOD) in mesostructured silica. The enzyme is incorporated into the silica framework via a direct one-step immobilization method. Results obtained by SAXS and nitrogen adsorption-desorption analysis clearly show that the channel arrangement of the recovered materials depends on the GOD loading. Indeed, when the hydrothermal treatment is performed at 60 °C for 2 days, well-ordered materials are obtained if the GOD concentration is lower than 3.2 mg per mL of micellar solution, and higher loading leads to the formation of wormhole-like structures. The efficiency of the immobilization was revealed by fluorescence and FTIR spectroscopy. It appears that there is a maximum loading of GOD, about 11 wt %, that can be incorporated into the matrix. Results also show that the surfactant plays the role of a pore-forming agent. Finally, we have shown that the entrapped enzyme maintains its activity.

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Section: Introductionmentioning

confidence: 99%

“…These authors reported in 1962 an enzyme electrode for measuring glucose concentrations. Since this study, many papers dealing with enzyme-based biosensors have been published in the literature. − Because of its importance in the human metabolism, glucose is the most studied analyte …”

Section: Introductionmentioning

confidence: 99%