Analytical challenges in characterization of high purity materials

Abstract

Available analytical literature reveals that it is possible to identify a lot of procedures to carry out any determination using a plethora of analytical techniques. The fundamental analytical requirements for realizing the desired and acceptable information from a chemical analysis are representative nature of the sample, precision, accuracy, selectivity and sensitivity. These decide, to a larger extent, the selection of the most appropriate methodology in order to obtain chemical information from a system. A number of analytical methodologies are being used in the author's laboratory for carrying out trace elemental analysis as a part of chemical quality control. Quite a good number of analytical challenges with specific reference to the characterization of high purity materials of relevance to nuclear technology were addressed and methodologies were developed for trace elemental analysis of both metallic and non-metallic constituents. A brief review of these analytical challenges and the analytical methodologies developed and also the future needs of analytical chemist are presented in this paper.

Establishment and Validation of an Analytical Technique for Quantification of Trace Metallic Elements in Uranium-Zirconium Fuel Ingot Employing Time of Flight-based ICP-MS

“…The instrumental operating conditions are given in Table I. The monitored isotopes of the analytes under consideration are tabulated in Table II. To minimize instrumental drift, data acquisition was done 1 hour after plasma ignition (33).…”

Preparation and physicochemical characterization of ingredients of Indian traditional medicine, Mahamrutyunjaya Rasa

“…The purification procedures are also well documented but none of the methods have been studied in detail to determine the structural and chemical changes taking place in the ingredients, which is essential requirement to discuss the non-toxicity and therapeutic value of such formulations. Since these preparations are sustaining themselves since centuries in clinical use, therefore one cannot exclude its use [11] . In this report, an attempt was made to derive certain standard data which may form the basis of quality control of the raw materials present in the formulation.…”