Analytical Assessment of Sodium Isfet Based Sensors for Sweat Analysis

Rovira, Meritxell; Lafaye, Céline; Wang, Shu; Fernández‐Sánchez, César; Saubade, Mathieu; Liu, Shih-Chii; Jiménez-Jorquera, Cecilia

doi:10.2139/ssrn.4374306

Cited by 1 publication

(1 citation statement)

References 44 publications

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“…An ion-sensitive field-effect transistor (ISFET) was first reported in the 1970s [ 9 ]. This field-effect transistor (FET)-type sensor system offers numerous advantages, such as fast response, label-free detection, and compatibility with the complementary metal-oxide-semiconductor (CMOS) process [ 10 , 11 , 12 , 13 ]. The concept of ISFETs has been further advanced to an extended-gate field-effect transistor (EGFET) structure, which comprises a separated extended gate (EG) sensing unit and an FET transducer unit [ 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Pushing the Limits of Biosensing: Selective Calcium Ion Detection with High Sensitivity via High-k Gate Dielectric Engineered Si Nanowire Random Network Channel Dual-Gate Field-Effect Transistors

Hyun

Cho

2023

Sensors

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Calcium ions (Ca2+) are abundantly present in the human body; they perform essential roles in various biological functions. In this study, we propose a highly sensitive and selective biosensor platform for Ca2+ detection, which comprises a dual-gate (DG) field-effect transistor (FET) with a high-k engineered gate dielectric, silicon nanowire (SiNW) random network channel, and Ca2+-selective extended gate. The SiNW channel device, which was fabricated via the template transfer method, exhibits superior Ca2+ sensing characteristics compared to conventional film channel devices. An exceptionally high Ca2+ sensitivity of 208.25 mV/dec was achieved through the self-amplification of capacitively coupled DG operation and an enhanced amplification ratio resulting from the high surface-to-volume ratio of the SiNW channel. The SiNW channel device demonstrated stable and reliable sensing characteristics, as evidenced by minimal hysteresis and drift effects, with the hysteresis voltage and drift rate measuring less than 6.53% of the Ca2+ sensitivity. Furthermore, the Ca2+-selective characteristics of the biosensor platform were elucidated through experiments with pH buffer, NaCl, and KCl solutions, wherein the sensitivities of the interfering ions were below 7.82% compared to the Ca2+ sensitivity. The proposed Ca2+-selective biosensor platform exhibits exceptional performance and holds great potential in various biosensing fields.

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